标题：交感神经及其神经递质调控间充质干细胞的研究进展

      作者：陈美雄 1，郑凯 2，徐明奎 1，袁仕国 1    1.海南省中医院骨伤科，海南 海口 570203；2.右江民族医学院基础医学院，广西 百色 533000

      卷次： 2023年34卷2期

      【摘要】 间充质干细胞(MSCs)属于成体干细胞，主要存在于结缔组织和器官间质中，是组织损伤修复、衰老改变等的关键。近来研究发现交感神经及其神经递质对MSCs的动员、归巢、增殖、分化，以及干细胞巢、微环境等存在多位点、多阶段的影响和调控。本文拟总结交感神经及其神经递质介导、调控MSCs的相关研究，为MSCs的进一步研究、应用等提供参考和思路。
      【关键词】 自主神经系统；交感神经受体；间充质干细胞；微环境；去甲肾上腺素
      【中图分类号】 R338 【文献标识码】 A 【文章编号】 1003—6350（2023）02—0291—04

Research progress of mesenchymal stem cells regulated by sympathetic nerve and its neurotransmitters.
CHENMei-xiong 1, ZHENG Kai 2, XU Ming-kui 1, YUAN Shi-guo 1. 1. Derpartment of Orthopedics and Traumatology, HainanTraditional Chinese Medicine Hospital, Haikou 570203, Hainan, CHINA; 2. School of Basic Medical Sciences, YoujiangMedical University for Nationalities, Baise 533000, Guangxi, CHINA【Abstract】 Mesenchymal stem cells (MSCs) are adult stem cells, which mainly exist in connective tissue and or-gan stroma. They are the key to tissue damage repair and aging changes. Recent studies have found that sympatheticnerve and its neurotransmitters have multi-point and multi-stage effects and regulation on the mobilization, homing, pro-liferation, and differentiation of MSCs, as well as stem cell niche and microenvironment. This paper intends to summa-rize the related research of sympathetic nerve and its neurotransmitter-mediated and regulated MSCs, so as to provide ref-erence and ideas for the further research and application of MSCs.
      【Key words】 Autonomic nervous system; Sympathetic receptor; Mesenchymal stem cell; Microenvironment;Norepinephrine　　　·综述·doi:10.3969/j.issn.1003-6350.2023.02.033基金项目：海南省自然科学基金(编号：822MS183)；海南省临床医学中心建设项目资助(编号：琼卫医函[2021]276号)。第一作者：陈美雄(1964—)，男，主任医师，主要研究方向为骨伤科疾病诊治。