标题：手足口病患者肠道微生物特征及其对疾病影响的研究进展

      作者：杨灵康 1，葛盈露 1，李文昌 1，撒楠 1，王鹏 1，史永林 1，张明珠 2，孙永 1    杨灵康 1，葛盈露 1，李文昌 1，撒楠 1，王鹏 1，史永林 1，张明珠 2，孙永 11.安徽省疾病预防控制中心，安徽 合肥 230601；2.合肥工业大学食品与生物工程学院，安徽 合肥 230601

      卷次： 2024年35卷14期

      【摘要】 手足口病(HFMD)是一种由肠道病毒引起的主要影响儿童的传染性疾病，其与肠道微生物之间的关联特征近年来受到了广泛关注。肠道微生物是指生活在人体消化道中并与人体共生的微生物，这类微生物与人体健康息息相关。多组学技术已被广泛用于肠道微生物和微生物衍生代谢物的鉴定和表征，了解肠道微生物与HFMD之间的相互作用不仅是研究需要，也是HFMD感染预防和治疗措施的发展方向。本综述旨在了解HFMD人群肠道菌群和病毒组，并着重介绍肠道微生物在HFMD中免疫稳态的相关作用，以期为HFMD的诊断和防治提供新思路。
      【关键词】 手足口病；肠道微生物；多组学技术；肠道屏障
      【中图分类号】 R511 【文献标识码】 A 【文章编号】 1003—6350（2024）14—2123—06

Advances in research on the characteristics of intestinal microbiota and its impact on the disease in patients withhand, foot, and mouth disease.
YANG Ling-kang 1, GE Ying-lu 1, LI Wen-chang 1, SA Nan 1, WANG Peng 1, SHI Yong-lin 1,ZHANG Ming-zhu 2, SUN Yong 1. 1. Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, Anhui,CHINA; 2. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, Anhui, CHINA【Abstract】 Hand, foot, and mouth disease (HFMD) is an infectious disease caused by enteroviruses that mainlyaffect children, and its association with gut microbes has attracted extensive attention in recent years. Intestinal microbio-ta, which comprises microorganisms residing in the human digestive tract and engaging in symbiotic interactions withthe host, plays a critical role in human health. Multi-omics technologies have been extensively utilized to identify andcharacterize intestinal microbiota and microbe-derived metabolites. Investigating the interactions between intestinal mi-crobiota and HFMD is essential for advancing our understanding and developing preventive and therapeutic measuresfor HFMD infection. This review aims to understand the intestinal microbiota and virome in HFMD populations and tounderscore the role of intestinal microbiota in maintaining immune homeostasis in HFMD, with the hope to offer newperspectives for the diagnosis, prevention, and treatment of HFMD.
      【Key words】 Hand, foot, and mouth disease; Intestinal microbiota; Multi-omics technologies; Intestinal barrier