标题：阿司匹林对原发性高血压患者外周血淋巴细胞比值的影响

      作者：田蕾，吴春怡，任涛    (上海市闵行区莘庄社区卫生服务中心，上海 201100)

      卷次： 2018年29卷20期

      【摘要】 目的 探究阿司匹林对原发性高血压患者外周血中性粒细胞与淋巴细胞比值(NLR)的影响。方法 选取 2016年 7月至 2017年 7月在上海市莘庄社区卫生服务中心进行体检，确定为原发性高血压的 160例患者作为研究对象，采用随机数表法将患者分为对照组和观察组各80例。两组患者均采用改变生活方式和口服复方降压片对血压进行控制，观察组患者在此基础上口服阿司匹林肠溶片进行治疗，服用剂量为 100 mg/d，连续服用 3个月后比较两组患者外周血NLR比值、血压、血小板和血液流变学等指标，对阿司匹林的治疗效果进行评价。结果 治疗前两组患者的外周血NLR比值、血压、血小板和血液流变学指标比较，差异均无统计学意义(P>0.05)；治疗后观察组患者的外周血NLR比值为(1.26±0.57)，明显低于对照组的(2.58±0.48)，收缩压为(132.06±8.66) mmHg，舒张压为(82.20±6.14) mmHg，均明显低于对照组的(138.53±7.12 ) mmHg和(87.89±4.45) mmHg，差异均有统计学意义(P<0.05)；观察组患者的血小板计数为(160.32±21.06)×109/L，平均血小板体积为(8.45±0.74) fl，血小板分布宽度为(14.41±0.75)，低于对照组的(183.16±16.46) ×109/L、(9.32±0.36) fl、(15.37±0.68)，差异均有统计学意义(P<0.05)；观察组患者的高切血黏度为(4.37±0.26) mPa·s，低切血黏度为(9.66±1.43) mPa·s，血液黏度为(1.32±0.08) mPa·s，均明显低于对照组的(5.90±0.21) mPa·s、(12.17±1.63) mPa·s、(1.48±0.02) mPa·s，差异均有统计学意义(P<0.05)。结论 阿司匹林可以显著降低原发性高血压患者外周血的NLR比值，控制血压，调节血小板功能，降低血液黏稠度。
      【关键词】 阿司匹林；原发性高血压；外周血；中性粒细胞与淋巴细胞比值
      【中图分类号】 R544.1 【文献标识码】 A 【文章编号】 1003—6350（2018）20—2830—03

Effect of aspirin on peripheral blood neutrophil-to-lymphocyte ratio in patients with essential hypertension.TIAN Lei, WU Chun-yi, REN Tao.
The Xinzhuang Community Health Service Center of Minhang District of Shanghai City,Shanghai 201100, CHINA
【Abstract】 Objective To explore the effect of aspirin on neutrophil-to-lymphocyte ratio (NLR) of peripheralblood in patients with essential hypertension. Methods A total of 160 patients diagnosed as essential hypertension inthe Xinzhuang Community Health Service Center of Minhang District of Shanghai City during July 2016 to July 2017were selected as the research objects. The patients were assigned into the control group and the experimental group ac-cording to random number table method, with 80 cases in each group. The two groups of patients were treated with life-style-changing and oral combination antihypertensive tablets to control blood pressure, and the patients in the experimen-tal group continuously take orally aspirin enteric-coated tablets on the basis of the above methods for three month, at thedose of 100 mg/day. The therapeutic effect of aspirin was evaluated by comparing the NLR of peripheral blood, bloodpressure, platelet and hemorheology of the two groups. Results There was no significant difference in peripheral bloodNLR, blood pressure, platelet and hemorheology between the two groups before treatment (P>0.05). After treatment,the NLR of peripheral blood in the observation group was (1.26±0.57), which was significantly lower than (2.58±0.48)in the control group (P>0.05). The systolic blood pressure and diastolic blood pressure of the observation groupwere (132.06±8.66) mmHg and (82.20±6.14) mmHg, respectively, which were significantly lower than corresponding(138.53±7.12) mmHg and (87.89±4.45) mmHg of the control group (P>0.05). The platelet count, mean platelet volume,platelet distribution width of the observation group were (160.32±21.06)×109/L, (8.45±0.74) fl, (14.41±0.75), respective-·论 著·doi:10.3969/j.issn.1003-6350.2018.20.006基金项目：上海市闵行区卫生和计划生育委员会科研课题(编号：2016MW54)