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      标题:血清TNF-α、IL-6检测对婴幼儿细菌性肺炎病情和预后判断的价值
      作者:李健雄 1,陆映昭 2,曾丽韫 2    (东莞市企石医院检验科 1、儿科 2,广东 东莞 523500)
      卷次: 2018年29卷19期
      【摘要】 目的 探讨血清肿瘤坏死因子-α (TNF-α)和白细胞介素-6 (IL-6)检测对婴幼儿细菌性肺炎病情和预后判断的指导价值,以期为临床上婴幼儿细菌性肺炎的诊治提供指导。方法 回顾性分析东莞市企石医院儿科于2017年6月至2018年2月期间收治的48例细菌性肺炎患儿的临床资料,根据小儿危重病例评分(PCIS)将患儿分成危重病例(观察组,n=18)和非危重病例(对照组,n=30),根据临床疗效将其分成预后良好组(n=34)及预后不佳组(n=14)。比较不同组别患儿血清的TNF-α和 IL-6水平。结果 观察组患儿血清TNF-α、IL-6水平分别为(37.81±6.37)pg/mL、(26.19±5.02) pg/mL,明显高于对照组的(32.27±7.42) pg/mL、(20.34±6.14) pg/mL,差异均有统计学意义(P<0.05);预后不佳组患儿的血清TNF-α、IL-6水平分别为(40.25±6.43) pg/mL、(28.29±5.67) pg/mL,明显高于预后良好组的(33.49±6.94) pg/mL、(22.16±5.72) pg/mL,差异有统计学意义(P<0.05)。结论 血清TNF-α和 IL-6水平在婴幼儿细菌性肺炎的发病过程中发挥着重要的调节作用,二者联合检测有助于患儿的病情评估及预后判断。
      【关键词】 肺炎;炎症反应;肿瘤坏死因子-α;白细胞介素-6;预后
      【中图分类号】 R725.6 【文献标识码】 A 【文章编号】 1003—6350(2018)19—2717—03
Value of serum TNF-α and IL-6 detection in the diagnosis and prognosis prediction of infantile bacterialpneumonia. LI Jian-xiong 1, LU Ying-zhao 2, ZENG Li-yun 2. Department of Clinical Laboratory 1, Department of Pediatrics 2,Dongguan Qishi Hospital, Dongguan 523500, Guangdong, CHINA
      【Abstract】 Objective To investigate the guiding value of serum tumor necrosis factor-α (TNF-α) and interleu-kin-6 (IL-6) detection in the diagnosis and prognosis prediction of infants with bacterial pneumonia, in order to provideguidance for the clinical diagnosis and treatment of infantile bacterial pneumonia. Methods A retrospective analysiswas conducted using clinical data of 48 children with bacterial pneumonia admitted to the Department of Pediatrics inDongguan Qishi Hospital from June 2017 to February 2018. According to the pediatrics critical illness score (PCIS),these children were classified into critical cases (observation group, n=18) and non-critical cases (control group, n=30),and they were also divided into a good prognosis group (n=34) and a poor prognosis group (n=14) according to their clin-·论 著·doi:10.3969/j.issn.1003-6350.2018.19.015
      基金项目:广东省东莞市社会科技发展一般项目(编号:2018507150121540)

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