标题：MicroRNAs-急性心肌梗死新型生物标志物

      作者：李国斌，周振宇 综述 刘涛 审校    (川北医学院第二临床医学院南充市中心医院心内科，四川 南充 637000)

      卷次： 2018年29卷18期

      【摘要】 冠状动脉疾病及其并发症是全球最常见的死亡病因，心肌肌钙蛋白是目前用于急性心肌梗死诊断和风险分级的标准生物标志物。加大力度开发额外的新型标志物可以更加有效和安全地排除心梗患者。在过去的十年中，microRNAs已成为包括AMI在内多种疾病的新型潜在诊断生物标志物。文章旨在总结该领域的一些重要研究，并讨论microRNAs在AMI诊断及预后的潜在价值。
      【关键词】 急性心肌梗死；microRNAs；生物标志物；动脉粥样硬化斑块
      【中图分类号】 R542.2+2 【文献标识码】 A 【文章编号】 1003—6350（2018）18—2588—04

MicroRNAs—new biomarkers of acute myocardial infarction.
LI Guo-bin, ZHOU Zhen-yu, LIU Tao. NanchongCentral Hospital/the Second Clinical Medical School of North Sichuan Medical College, Nanchong 637000, Sichuan, CHINA【Abstract】 Coronary artery disease and its complications remain the most common cause of death worldwide.Cardiac troponins are standard biomarkers used today for diagnosis and risk stratification of acute myocardial infarction.Increasing efforts are made to develop additional new biomarkers for more effective and safe rule-in and rule-out of AMIpatients. During the past decade, microRNAs have emerged as new, potential diagnostic biomarkers in several diseases,including AMI. The review aimed to summarize some of the prominent studies in the field, and discuss the potential val-ue of microRNAs in the diagnosis and prognosis of AMI.
      【Key words】 Acute myocardial infarction; microRNAs; Biomarkers; Atherosclerotic plaque·综 述·doi:10.3969/j.issn.1003-6350.2018.18.022基金项目：四川省南充市科技项目(编号：NSMC20170456)