标题：3D生物打印在软骨组织工程中的研究进展

      作者：黄志望 1，黄江鸿 2，3，4，梁仟 1，王大平 2，3，4，熊建义 2，3，4    (1.汕头大学医学院，广东 汕头 515063；2.深圳市第二人民医院国家重点骨科，广东 深圳 518035；3.深圳市组织工程重点实验室，广东 深圳 518035；4.深圳市数字骨科技术工程实验室，广东 深圳 518035)

      卷次： 2018年29卷18期

      【摘要】 3D生物打印是增材制造快速成型技术中的一个分支，能精确控制细胞、生物材料及生物因子在空间上的组装，并按需实现个性化构建宏观及微观的结构。该技术的出现除了能实现个性化修复组织和器官外，还为器官移植技术解决器官来源和排异反应提供了一个新思路，让直接修复活组织和器官成为可能，在软骨组织工程的研究应用中具有巨大的潜力。本文主要综述了3D生物打印的原理、方法以及在软骨组织工程中常用生物墨水材料的应用的最新研究进展。
      【关键词】 3D生物打印；生物墨水；软骨组织工程
      【中图分类号】 R681.3 【文献标识码】 A 【文章编号】 1003—6350（2018）18—2577—05

Research progress of 3D bioprinting in cartilage tissue engineering.
HUANG Zhi-wang 1, HUANG Jiang-hong 2, 3, 4,LIANG Qian 1, WANG Da-ping 2, 3 ,4, XIONG Jian-yi 2, 3, 4. 1. Shantou University Medical College, Shantou 515063, Guangdong,CHINA; 2. Shenzhen National Key Department of Orthopedics, Shenzhen Second People's Hospital, Shenzhen 518035,Guangdong, CHINA; 3. Shenzhen Key Laboratory of Tissue Engineering, Shenzhen 518035, Guangdong, CHINA; 4. ShenzhenLaboratory of Digital Orthopedic Engineering, Shenzhen 518035, Guangdong, CHINA【Abstract】 Three dimensional (3D) bioprinting is a branch of the rapid prototyping technology, which can pre-cisely control the assembly of cells, biomaterials and biological factors in space, and enables the individualized construc-tion of macro and micro structures on demand. In addition to realize the individualized repair of tissues and organs, theemergence of this technology also provides a new idea for organ transplantation technology to solve organ source and re-jection, making it possible to repair living tissues and organs directly, and has great potential in the research and applica-tion of cartilage tissue engineering. This paper mainly reviews the principles and methods of 3D bioprinting, and the lat-est research progress in the application of bio-ink materials commonly used in cartilage tissue engineering.
      【Key words】 3D bioprinting; Bio-ink; Cartilage tissue engineering·综 述·doi:10.3969/j.issn.1003-6350.2018.18.019基金项目：广东省科技计划项目(编号：2017A020215116)；广东省医学科研基金项目(编号：A2017189)；广东省深圳市科技计划项目(编号：JCYJ20160301111338144、JCYJ20170306092315034)