标题：十堰市2~6岁儿童幽门螺杆菌感染情况及影响因素

      作者：张敏 1，王斌 2，周春芳 2，黄小明 3，林丽 4    (1.十堰市人民医院白浪分院消化内科，湖北 十堰 442000；2.十堰市人民医院消化内科，湖北 十堰 442000；3.西南医科大学公共卫生学院营养与食品卫生学教研室，四川 泸州 646000；4.十堰市太和医院检验科，湖北 十堰 442000)

      卷次： 2018年29卷18期

      【摘要】 目的 调查十堰市2~6岁儿童幽门螺杆菌(Hp)感染情况，探讨幽门螺杆菌感染的影响因素，为预防儿童Hp感染提供指导依据。方法 选取 2015年 1月至 2017年 12月于十堰市太和医院进行Hp检测的 2~6岁儿童1 577人，用粪便抗原试验(Hp SAT)检测Hp感染情况，多因素Logistic回归分析Hp感染的影响因素。结果 十堰市学龄前儿童Hp感染率为21.3%，感染率随年龄增加而上升；单因素分析发现分餐习惯、家庭人员数、父母文化程度、家庭成员消化道疾病史和父母卫生习惯等是Hp感染的影响因素(P<0.05)；多因素Logistic回归分析结果显示，独立餐具是Hp感染的保护因素(OR=0.543，95%CI=0.307~0.958)，家庭成员数>3人(OR=2.024，95%CI=1.185~3.456)和家庭成员有消化道疾病史(OR=2.404，95%CI=1.537~3.758)是Hp感染的危险因素。结论 十堰市2~6岁儿童Hp感染率较高，家庭成员间相互传染可能是儿童感染Hp的重要途径，儿童应独立使用餐具和漱口杯并定期消毒，以预防Hp感染。
      【关键词】 幽门螺杆菌；儿童；感染；影响因素
      【中图分类号】 R725.3 【文献标识码】 A 【文章编号】 1003—6350（2018）18—2555—03

Infection status and influencing factors of Helicobacter pylori among 2 to 6 year-old children in Shiyan City.ZHANG Min 1, WANG Bin 2, ZHOU Chun-fang 2, HUANG Xiao-ming 3, LIN Li 4.
1. Department of Gastroenterology, BailangBranch of Shiyan People's Hospital, Shiyan 442000, Hubei, CHINA; 2. Department of Gastroenterology, Shiyan People'sHospital, Shiyan 442000, Hubei, CHINA；3. Department of Nutrition and Food Hygiene, Southwest Medical University,Luzhou 646000, Sichuan, CHINA；4. Department of Clinical Laboraty, Taihe Hospital , Shiyan City, Shiyan 442000, Hubei,CHINA
【Abstract】 Objective To investigate the Helicobacter pylori (Hp) infection and its influencing factors of 2-6year-old children in Shiyan city, and provide guidance for prevention of HP infection in children. Methods From Janu-ary 2015 to December 2017, 1 577 preschool children aged 2 to 6 year-old undergoing Hp test in Taihe Hospital, ShiyanCity were selected. The Hp infection was detected by Hp stool antigen test (Hp SAT), and the influencing factors of Hpinfection was analyzed by multiple factor Logistic regression. Results The Hp infection rate of preschool children was21.3%. The infection rate increased with the increase of age. Univariate analysis showed that eating habits, number offamily members, parents' educational level, family history of digestive diseases and parental health habits were the influ-encing factors of Hp infection (P<0.05). Multiple factor Logistic regression showed that independent tableware was pro-tecting factor of Hp infection (OR=0.543 and 95%CI=0.307-0.958), while over 3 family members (OR=2.024，95%CI=1.185-3.456) and family history of digestive diseases (OR=2.404, 95%CI=1.537-3.758) were risk factors of Hp infec-tion. Conclusion The Hp infection rate of preschool children is high in Shiyan City. Transmission among family mem-bers may be an important way for children to be infected with HP. Tableware and mouthwash cups should be provided in-dependently for children and sterilized regularly to prevent HP infection.
      【Key words】 Helicobacter pylori (Hp); Children; Infection; Influencing factors·论 著·doi:10.3969/j.issn.1003-6350.2018.18.012基金项目：湖北省十堰市科技局市级科学技术研究与开发专项(编号：16K70)