标题：粪便钙卫蛋白在新生儿坏死性小肠结肠炎诊断中的应用

      作者：王辉 1，冯宗太 2，杨祖铭 1，王三南 1，杨晓路 1    (1.南京医科大学附属苏州医院新生儿科，江苏 苏州 215002；2.苏州大学附属儿童医院普外科，江苏 苏州 215003)

      卷次： 2018年29卷17期

      【摘要】 目的 研究粪便钙卫蛋白(Fc)在新生儿坏死性小肠结肠炎(NEC)诊断中的价值。方法 以2015年3月至2016年9月入住南京医科大学附属苏州医院新生儿科的NEC患儿40例为NEC组，同一时期因非感染性疾病住院的 40例新生儿为对照组，采集粪便样本，采用酶联免疫法检测 Fc水平。结果 NEC组患儿在NEC开始禁食时 Fc水平为(405.5±19.3) μg/g，明显高于对照组的(180.5±25.2) μg/g，差异有统计学意义(P<0.05)；NEC患儿治疗好转后拟重新开奶时的 Fc水平为(186.9±23.5) μg/g，与对照组的(180.5±25.2) μg/g比较差异无统计学意义(P>0.05)。结论 Fc在NEC发生时明显升高，治疗好转后其值降低，Fc对NEC早期诊疗有一定的价值
      【关键词】 粪便钙卫蛋白；坏死性小肠结肠炎；新生儿
      【中图分类号】 R725.7 【文献标识码】 A 【文章编号】 1003—6350（2018）17—2493—03

Application of fecal calprotectin in the diagnosis of neonatal necrotizing enterocolitis.
WANG Hui 1, FENG Zong-tai 2,YANG Zu-ming 1, WANG San-nan 1, YANG Xiao-lu1. 1. Department of Neonatology, Suzhou Municipal Hospital (NanjingMedical University Affiliated Suzhou Hospital), Suzhou 215002, Jiangsu, CHINA; 2. Department of General Surgery,Children's Hospital of Soochow University, Suzhou 215003, Jiangsu, CHINA
【Abstract】 Objective To explore the value of fecal calprotectin (Fc) in the diagnosis of neonatal necrotizingenterocolitis (NEC). Methods Forty neonates with NEC who were admitted to the Department of Neonatology inNanjing Medical University Affiliated Suzhou Hospital. During March 2015 and September 2016 were enrolled inNEC group. During the same period, 40 newborns hospitalized for non-infectious diseases were taken as controlgroup. Fecal samples were collected and the levels of Fc were detected by enzyme-linked immunosorbent assay (ELI-SA). Results The Fc level of NEC group at the start of fasting was (405.5±19.3) μg/g, which was significantly higherthan (180.5±25.2) μg/g in the control group (P<0.05). After therapy, the levels of Fc in the NEC group at the time ofready-to-refeed was (186.9±23.5) μg/g compared to (180.5±25.2) μg/g in the control group (P>0.05). Conclusion Fc issignificantly elevated in the occurrence of NEC and reduced after treatment. Fc has certain value for early diagnosis andtreatment of NEC.
      【Key words】 Fecal calprotectin; Necrotizing enterocolitis; Neonates·临床经验·doi:10.3969/j.issn.1003-6350.2018.17.036基金项目：江苏省苏州市科技支撑计划项目(编号：SYSD2012104)