标题：长链多聚磷酸盐的合成、降解、检测及临床意义

      作者：杨晓阳 1，万梦婕 1，王智明 1，陈方平 2    (1.中南大学湘雅医学院附属海口医院暨海口市人民医院血液科，海南 海口 570208；2.中南大学湘雅医院血液科，湖南 长沙 410008)

      卷次： 2018年29卷17期

      【摘要】 长链多聚磷酸盐是经多个高能磷酸键连接的线性无机磷酸盐，其磷酸基团从几十到上千不等。长链多聚磷酸盐普遍存在于包括人体在内的动植物及微生物中，但由于长期缺少转化医学切入点，很长时间被认为是“分子化石”，无重要的生理功能。直到近期发现其可能通过激活凝血因子Ⅻ以及缓激肽系统等引起炎症和凝血异常。但目前对长链多聚磷酸盐的认识尚少，为了提高对长链多聚磷酸盐的了解和关注，本文从长链多聚磷酸盐的合成、降解、检测及临床意义等方面对其进行讨论，希望能起到抛砖引玉的作用。
      【关键词】 长链多聚磷酸盐；凝血；炎症；血小板聚集
      【中图分类号】 R589.4 【文献标识码】 A 【文章编号】 1003—6350（2018）17—2471—03

Synthesis, degradation, detection and clinical significance of long chain polyphosphate.
YANG Xiao-yang 1, WANMeng-jie 1, WANG Zhi-ming 1, CHEN Fang-ping 2. 1. Department of Hematology, Central South University Xiangya Schoolof Medicine Affiliated Haikou Hospital (Haikou People's Hospital), Haikou 570208, Hainan, CHINA; 2. Department ofHematology, Xiangya Hospital Central South University, Changsha 410008, Hunan, CHINA【Abstract】 Long chain polyphosphates are linear inorganic phosphates linked by multiple high-energy phos-phate bonds with phosphate groups ranging from tens to thousands. Long chain polyphosphates are generally found inanimals, plants and microorganisms, including humans. However, due to the long-term lack of entry points in translation-al medicine, they have been considered as“molecular fossils”for a long time and have no important physiological func-tions. It has only recently been discovered that they may cause inflammation and coagulation abnormalities by activatingthe coagulation factor Ⅻ and the bradykinin system. But there is still little understanding of long chain polyphosphates.This paper discusses the synthesis, degradation, detection and clinical significance of long chain polyphosphates to im-prove the understanding and concern of long chain polyphosphates, and moreover, to throw out a minnow to catch a whale.
      【Key words】 Long chain polyphosphates; Coagulation; Inflammation; Platelet aggregation·综 述·doi:10.3969/j.issn.1003-6350.2018.17.029基金项目：海南省卫生和计划生育委员会项目(编号：16A200009)