标题：雌激素对颅脑创伤的保护作用及其主要机制

      作者：许辰，封启明    (上海交通大学附属第六人民医院急诊医学科，上海 200233)

      卷次： 2018年29卷17期

      【摘要】 大量的动物实验表明颅脑创伤动物的预后存在明显的性别差异，雌性动物的预后优于雄性。相关研究证实雌激素对于颅脑创伤具有明显的保护作用，创伤动物应用雌激素能够显著改善其预后。关于其具体作用机制，国内外已有许多研究。本文主要综述雌激素对于颅脑创伤发挥保护作用的具体机制。
      【关键词】 颅脑创伤；雌激素；预后
      【中图分类号】 R651.1+5 【文献标识码】 A 【文章编号】 1003—6350（2018）17—2468—03

Protective effect of estrogen on craniocerebral trauma and its main mechanism.
XU Chen, FENG Qi-ming. Departmentof Emergency Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, CHINA【Abstract】 Lots of animal experiments have shown that obvious gender differences exist in the prognosis of ani-mals which undergo craniocerebral trauma, and that the prognosis of female animals is better than that of males. Relatedresearches have confirmed that estrogens could provide significant protection to craniocerebral, trauma, and that theprognosis of the traumatic animals undergoing estrogen treatment could be improved significantly. There have beenmany researches at home and abroad illustrating the specific mechanism. This article summaries the specific mechanismof the protective effect of estrogen on craniocerebral trauma.
      【Key words】 Craniocerebral trauma; Estrogen; Prognosis·综 述·doi:10.3969/j.issn.1003-6350.2018.17.028基金项目：国家临床重点专科建设项目(编号：国卫办医函2013544号)