标题：凝血因子Ⅻ的研究进展

      作者：黄天卓    (广东医科大学，广东 湛江 524023)

      卷次： 2018年29卷17期

      【摘要】 凝血因子Ⅻ (FⅫ)是一种血浆蛋白酶，其活化后可以激活促进凝血和炎症反应的接触系统。FⅫ可以通过和多种物质接触而被激活，例如肥大细胞产生的肝磷脂、错误折叠的蛋白、胶原蛋白、核酸、多聚磷酸盐等。由于FⅫ基因缺陷并不会造成明显的出血，因此几十年来都被认为在体内凝血反应中可有可无。但近年来，人们发现了FⅫ在某些凝血和炎症性疾病中起关键作用。本文综述了FⅫ在血栓和炎症等相关疾病方面研究的进展，为将FⅫ作为新的治疗血栓栓塞与炎症性疾病的药物作用靶点提供依据。
      【关键词】 凝血因子Ⅻ；接触系统；抑制剂；激活剂；
      【中图分类号】 R55 【文献标识码】 A 【文章编号】 1003—6350（2018）17—2463—05

Research progress of coagulation factor Ⅻ.
HUANG Tian-zhuo, Guangdong Medical University, Zhanjiang 524023,Guangdong, CHINA【Abstract】 Coagulation factorⅫ is a kind of plasma protease that activates the contact system that promotes co-agulation and inflammation. Factor Ⅻ can be activated by contacting with a variety of substances, such as heparin de-rived from Mast Cells, misfolded protein, collagen, nucleic acids, polyphosphate and so on. Since Factor Ⅻ genetic defi-ciency does not cause significant bleeding, it has been thought for decades that this factor is dispensable in the body'sblood clotting response. But in recent years, it has been found that FactorⅫ plays a key role in some clotting and inflam-matory diseases. This article reviews the progress of Factor Ⅻ in related diseases such as thrombosis and inflammation,and provides a basis for taking FactorⅫ as a new drug target for the treatment of thrombotic embolism and inflammation.
      【Key words】 Coagulation factorⅫ; Contact system; Inhibitor; Activator·综 述·doi:10.3969/j.issn.1003-6350.2018.17.027基金项目：国家自然科学基金(编号：31101639)