标题：BCL11B基因在血液系统恶性肿瘤中的研究进展

      作者：刘银，王亚妹，李冬娜，任立成    (海南医学院生物学教研室，海南 海口 571199)

      卷次： 2018年29卷17期

      【摘要】 BCL11基因是BCL家族的重要组成部分，与血液肿瘤的发生相关，而BCL11B基因是BCL11家族一个不可忽视的成员之一。BCL11B基因是一种重要的转录调控因子，同时也是一种肿瘤抑制基因。BCL11B基因不仅参与胸腺发生、T细胞增殖和分化等生物过程，同时也调控着淋巴造血系统的发育和增殖等。此外，BCL11B基因基因突变或者异常表达等还会导致白血病/淋巴瘤以及其他恶性肿瘤的发生。因此研究BCL11B基因能为肿瘤的发生及治疗提供理论依据。
      【关键词】 BCL11B；白血病；淋巴瘤；肿瘤
      【中图分类号】 R733 【文献标识码】 A 【文章编号】 1003—6350（2018）17—2459—05

Research progress of BCL11B gene in hematological malignancies.
LIU Yin, WANG Ya-mei, LI Dong-na, RENLi-cheng. Department of Biology, Hainan Medical University, Haikou 571199, Hainan, CHINA【Abstract】 The BCL11 gene is an important component of the BCL family and is associated with the develop-ment of hematological tumors, and the BCL11B gene is one of the most important members of the BCL11 family.BCL11B gene is an important transcriptional regulator and a tumor suppressor gene. BCL11B gene is involved not only inbiological processes such as thymusogenesis, T cell proliferation and differentiation, but also in the development and pro-liferation of the lymphatic hematopoietic system. In addition, mutations or abnormal expression of the BCL11B genemay lead to the development of leukemia/lymphoma and other malignant tumors. Therefore, the study of BCL11B genecan provide a theoretical basis for the occurrence and treatment of tumors.
      【Key words】 BCL11B; Leukemia; Lymphoma; Tumor·综 述·doi:10.3969/j.issn.1003-6350.2018.17.026基金项目：国家自然科学基金(编号：31260269、31660318)；海南省级大学生创新课题(编号：20150082)