标题：健康体检人群血清尿酸水平对血常规各指标的影响

      作者：武建军 1，2，彭志晴 1，曹秀堂 3，曾强 2，英明中 2    (1.中国人民解放军总医院海南分院保健科，海南 三亚 572000；2.中国人民解放军总医院南楼临床部健康管理研究院，北京 100853；3.中国人民解放军总医院医疗统计科，北京 100853)

      卷次： 2018年29卷17期

      【摘要】 目的 探讨健康体检人群血清尿酸水平对外周血常规各指标的影响。方法 以2015年1~12月在中国人民解放军总医院健康管理研究院国际部进行健康体检且资料完整的 9 167例体检人员作为研究对象，回顾总结研究对象的年龄、性别、体质量指数(BMI)、腰臀围比(WHR)、血常规、尿常规等指标。结果 9 167例体检者中男性6 171例，女性2 996例，年龄16~87岁，平均(49.41±8.98)岁，其中男性平均年龄(49.21±8.52)岁，女性(49.81±9.84)岁；人群总的高尿酸血症患病率为20.66% (1 894/9 167)；男性尿酸浓度为121~796 μmol/L，平均(379.51±77.69) μmol/L，女性为84~576 μmol/L，平均(270.13±57.88) μmol/L；男性高尿酸血症患病率为27.50%，明显高于女性的6.58%，差异有统计学意义(P<0.05)；男性组随年龄增加高尿酸血症患病率逐渐下降(P<0.05)，女性组随年龄增加高尿酸血症患病率增加(P<0.05)；男性高尿酸血症组的尿酸水平明显高于女性高尿酸组，正常尿酸组男女间比较差异也具有统计学意义(P<0.05)；BMI和WHR超标、尿液pH值较低的人群中，高尿酸血症患病率均明显高于正常指标范围内人群，差异均有统计学意义(P<0.05)；相关分析表明，血尿酸与血常规指标之间存在相关性，其中男性高尿酸组白细胞计数(r=0.064，P<0.05)、红细胞计数(r=0.063，P<0.05)、血小板计数(r=0.053，P<0.05)和血红蛋白(r=0.049，P<0.05)明显高于尿酸正常组并呈正相关，而尿酸水平与年龄呈负相关(r=-0.154，P<0.05)；女性组除中性粒细胞外，高尿酸组的年龄(r=0.151，P<0.05)和白细胞计数(r=0.13，P<0.05)、红细胞计数(r=0.126，P<0.05)、红细胞比积(r=0.137，P<0.05)、血红蛋白(r=0.158，P<0.05)和血小板计数(r=0.073，P<0.05)均高于正常尿酸组并呈正相关。结论 男性高尿酸血症患病率明显高于女性；BMI和WHR超标以及尿液pH值下降与高尿酸血症的发生有关；高尿酸血症引起外周血常规指标的一系列改变，血常规指标可作为观察高尿酸血症的生物学指标之一。
      【关键词】 高尿酸血症；体质指数；尿液pH值；血常规；健康体检
      【中图分类号】 R194.3 【文献标识码】 A 【文章编号】 1003—6350（2018）17—2428—04

Effect of serum uric acid level on blood routine parameters in healthy population.
WU Jian-jun 1,2, PENG Zhi-qing 1,CAO Xiu-tang 3, ZENG Qiang 2, YING Ming-zhong 2. 1. Department of Health Care, Hainan Branch, the General Hospital ofChinese People's Liberation Army, Sanya 572000, Hainan, CHINA; 2. Health Management Institute, the General Hospital ofChinese People's Liberation Army, Beijing 100853, CHINA; 3. Department of Medical Statistics, the General Hospital ofChinese People's Liberation Army, Beijing 100853, CHINA
【Abstract】 Objective To explore the effect of serum uric acid level on blood routine parameters in healthypopulation. Methods A total of 9 167 people undergoing medical examination and complete information in HealthManagement Institute, the General Hospital of Chinese People's Liberation Army were selected as research subjectsfrom January 2015 to December 2015. The age, sex, body mass index (BMI), waist hip ratio (WHR), blood routine ex-amination, and urine routine were retrospectively summarized. Results Among the 9 167 people, there were 6 171males and 2 996 females, aged 16~87 years, with an average of (49.41±8.98) years old, of which the average agewas (49.21±8.52) for males and (49.81±9.84) for females. The overall prevalence of hyperuricemia was 20.66%(1 894/9 167). The concentration of uric acid in males was (121~796) μmol/L, with an average of (379.51 ±77.69) μmol/L,while that in females was (84~557) μmol/L, with an average of (270.13±57.88) μmol/L. The prevalence of hyperurice-mia in males was 27.50%, which was significantly higher than 6.58% in females (P<0.05). The prevalence rate of hy-peruricemia decreased with age in male group, and increased with age in female group (P<0.05). The uric acid level inthe male HUA group was significantly higher than that in the female HUA group, and there was also significant differ-ence between males and females in normal uric acid group (P<0.05). The prevalence of hyperuricemia in people withexcess BMI and WHR and low urine pH value was significantly higher than that in people with normal index range,with statistically significant difference (P<0.05). Correlation analysis showed that there was correlations between se-rum uric acid and blood routine indexes. Among them, white blood cell count (r=0.064), red blood cell count (r=·论 著·doi:10.3969/j.issn.1003-6350.2018.17.018基金项目：海南省三亚市医疗卫生科技创新项目(编号：2017YW09)