标题：血清绒毛膜促性腺激素、孕酮水平与胚胎停止发育的关系

      作者：李忠辉，刘江美，梁冬儒    (东莞市樟木头医院妇产科，广东 东莞 523633)

      卷次： 2018年29卷13期

      【摘要】 目的 探讨血清绒毛膜促性腺激素(β-HCG)、孕酮(P)水平与胚胎停止发育的关系。方法 将2016年1月至2017年6月期间东莞市樟木头医院妇产科诊治的30例胚胎停止发育患者纳入胎停组，随机选择同期收治的30例早期正常妊娠孕妇纳入对照组，30例流产者纳入流产组。检测并比较三组受检者的血清β-HCG、P水平。结果 流产组与胎停组患者的血清β-HCG、P水平分别为(27 287±4 622) mIU/mL、(18.9±7.6) ng/mL和(6 430±1 672) mIU/mL、(14.8±4.3) ng/mL，均明显低于对照组的(96 465±14 225) mIU/mL、(57.3±26.8) ng/mL，而胎停组患者的血清β-HCG、P水平又明显低于流产组，差异有统计学意义(P<0.05)；妊娠早期孕妇血清β-HCG、P水平相关性分析结果显示，流产组孕妇血清β-HCG水平与 P水平有正相关性(P<0.05)，胎停组及对照组孕妇血清β-HCG与 P水平均无显著相关性(P>0.05)。结论 胚胎停止发育者其血清β-HCG、P水平明显降低，表明血清β-HCG、P水平偏低对预测胚胎发育的结局有一定的提示作用。
      【关键词】 胚胎发育停止；绒毛膜促性腺激素；孕酮；相关性
      【中图分类号】 R714.2 【文献标识码】 A 【文章编号】 1003—6350（2018）13—1877—02

Relationship between serum β-HCG, progesterone and embryonic arrest.
LI Zhong-hui, LIU Jiang-mei, LIANGDong-ru. Department of Obstetrics and Gynecology, Dongguan Zhangmutou Hospital, Dongguan 523633, Guangdong,CHINA
【Abstract】 Objective To investigate the relationship between serum β-HCG, progesterone (P) and embryonicarrest. Methods From January 2016 to June 2017, 30 patients of embryonic arrest in Department of Obstetrics and Gy-necology, Dongguan Zhangmutou Hospital were selected and enrolled as the embryonic arrest group, and 30 normalpregnant women of early period were selected as the control group. Besides, 30 women of abortion were selected as theabortion group. The serum levels of β-HCG, P were detected and compared between the three groups. Results The β-HCG,P were (27 287±4 622) mIU/mL, (18.9±7.6) ng/mL in abortion group and (6 430±1 672) mIU/mL, (14.8±4.3) ng/mL in em-bryonic arrest group, significantly lower than (96 465±14 225) mIU/mL, (57.3±26.8) ng/mL in the control group (P<0.05). The β-HCG, P levels in embryonic arrest group were significantly lower than those of the abortion group (P<0.05). The correlation analysis in early pregnancy showed that there was positive correlation between serum β-HCG lev-el and P level in abortion group (P<0.05), but there was no significant correlation between serum β-HCG and P levels inembryonic arrest group and control group (P>0.05). Conclusion The serum levels of serum β-HCG, P are significantlylower in embryonic arrest, which may be useful for predicting the outcome of embryonic development.
      【Key words】 Embryonic arrest; β-HCG; Progesterone; Correlation·临床经验·doi:10.3969/j.issn.1003-6350.2018.13.030