标题：血清胱抑素C在高胆红素血症新生儿中的变化及临床意义

      作者：杨荣敢，周祖发，陈媛媛    (中山火炬开发区医院儿科，广东 中山 528437)

      卷次： 2018年29卷13期

      【摘要】 目的 探讨血清胱抑素C (CysC)在高胆红素血症新生儿中的变化及临床意义。方法 选择中山火炬开发区医院儿科 2016年 1月至 2017年 10月期间收治的 95例高胆红素血症新生儿为研究对象，根据总胆红素(TbiL)水平分为轻度组(n=28)、中度组(n=32)和重度组(n=35)，选择30例健康新生儿纳入对照组。比较不同组别新生儿血清CysC、TbiL及血清肌酐(Scr)水平。结果 TbiL在对照组、轻度组、中度组及重度组新生儿中依次升高，CysC在轻度组、中度组及重度组依次升高，差异均有统计学意义(P<0.05)；Scr在轻度组、中度组及重度组依次升高，但差异无统计学意义(P>0.05)；Peason相关性分析结果显示，Scr与TbiL水平之间无相关性(r=0.136，P>0.05)，CysC与TbiL水平间有正相关性(r=0.681，P<0.05)。结论 高胆红素血症是新生儿常见疾病，可以出现不同程度的肾小球滤过率下降，且其程度与胆红素升高水平有相关性。
      【关键词】 高胆红素血症；胱抑素C；肾损伤；相关性
      【中图分类号】 R722.1 【文献标识码】 A 【文章编号】 1003—6350（2018）13—1833—03

Changes and clinical significance of serum cystatin C in neonates with hyperbilirubinemia.
YANG Rong-gan,ZHOU Zu-fa, CHEN Yuan-yuan. Department of Pediatrics, Hospital of Zhongshan Torch Development Zone, Zhongshan528437, Guangdong, CHINA
【Abstract】 Objective To investigate the changes and clinical significance of serum cystatin C (CysC) in neo-nates with hyperbilirubinemia. Methods A total of 95 neonates with hyperbilirubinemia, who admitted to the Hospitalof Zhongshan Torch Development Zone from January 2016 to October 2017, were selected and divided into the mildgroup (n=28), moderate group (n=32) and severe group (n=35) according to the total bilirubin (TbiL) level, and 30healthy newborns were selected as the control group. The levels of serum CysC, serum total bilirubin (TbiL) and serumcreatinine (Scr) in neonates of different groups were compared. Results TbiL increased gradually in the control group,mild group, moderate group and severe group, while the CysC increased gradually in the mild, moderate and severegroups, and the differences were statistically significant (P<0.05); Scr in the mild, moderate and severe groups increasedin turn, but the difference was not statistically significant (P>0.05). Pearson correlation analysis showed that there wasno correlation between SCr and TbiL (r=0.136, P>0.05), and there was a positive correlation between CysC and TbiL (r=0.681, P<0.05). Conclusion Hyperbilirubinemia is a common disease of newborn. It can reduce the glomerular filtra-tion rate of children to varying degrees, and its degree is related to the level of bilirubin.
      【Key words】 Hyperbilirubinemia; Cystatin C (CysC); Renal injury; Correlation·论 著·doi:10.3969/j.issn.1003-6350.2018.13.018基金项目：广东省中山市医学科研基金项目(编号：J2012299)