标题：孟鲁司特钠联合氨溴索治疗喘息性肺炎的疗效及其对患儿血清免疫球蛋白E水平的影响

      作者：张美霞，谭智雄，何浙海，胡义芝    (佛冈县人民医院儿科，广东 清远 511600)

      卷次： 2018年29卷13期

      【摘要】 目的 探讨孟鲁司特钠联合氨溴索治疗喘息性肺炎的疗效及其对患儿血清免疫球蛋白E(IgE)水平的影响。方法 选择佛冈县人民医院儿科2014年9月至2016年3月期间收治的96例喘息性肺炎患儿为研究对象，根据随机数表法分为对照组和观察组，每组48例。对照组患儿予常规抗病毒等常规治疗，观察组患儿则联合应用孟鲁司特钠和氨溴索治疗，疗程7 d。比较两组患儿的临床疗效及治疗前后血清 IgE水平。结果 治疗后，观察组患儿喘息、咳嗽及哮鸣音消退时间分别为(3.4±1.1) d、(4.2±1.3) d、(4.4±1.2) d，明显短于对照组的(3.9±1.3) d、(5.4±1.5) d、(5.6±1.6) d，血清 IgE水平为(168.2±40.7) IU/mL，明显低于对照组的(197.3±55.2) IU/mL，差异均有统计学意义(P<0.05)；观察组患儿的治疗有效率为95.83%，明显高于对照组的83.33%，差异有统计学意义(P<0.05)。结论 孟鲁司特钠联合氨溴索治疗喘息性肺炎可以有效降低血清 IgE水平，促进临床症状体征的缓解，提高临床疗效。
      【关键词】 喘息性肺炎；孟鲁司特钠；氨溴索；免疫球蛋白E；疗效
      【中图分类号】 R725.6 【文献标识码】 A 【文章编号】 1003—6350（2018）13—1805—03

Efficacy of montelukast sodium combined with ambroxol in the treatment of asthmatic pneumonia and its effecton serum immunoglobulin E level in children.
ZHANG Mei-xia, TAN Zhi-xiong, HE Zhe-hai, HU Yi-zhi. Departmentof Pediatrics, Fogang County People's Hospital, Qingyuan 511600, Guangdong, CHINA
【Abstract】 Objective To investigate the curative effect of montelukast sodium combined with ambroxol in thetreatment of asthmatic pneumonia and its effect on serum immunoglobulin E (IgE) level in children. Methods A totalof 96 children with asthmatic pneumonia treated in Department of Pediatrics, Fogang Country People's Hospital fromSeptember 2014 to March 2016 were selected as the research objects. According to random number table method, theywere divided into observation and control group, with 48 cases in each group. The control group was treated with con-ventional antiviral therapy, and the observation group was treated with montelukast sodium combined with ambroxol,with the course of treatment for 7 days. The clinical effect and the levels of serum IgE before and after treatment werecompared between the two groups. Results After treatment, the wheezing, coughing and wheezing subsided time in ob-servation group was (3.4±1.1) d, (4.2±1.3) d, (4.4±1.2) d, which were significantly shorter than (3.9±1.3) d, (5.4±1.5) d,(5.6±1.6) d in control group. The serum IgE level in observation group was (168.2±40.7) IU/mL, which was significantlylower than (197.3 ± 55.2) IU/mL in control group (P<0.05). The effective rate of the observation group was 95.83% ,which was significantly higher than 83.33% of control group (P<0.05). Conclusion Montelukast sodium combinedwith ambroxol in treating asthmatic pneumonia can effectively reduce the level of serum IgE, promote the relief of clini-cal symptoms signs, and improve the clinical efficacy.
      【Key words】 Asthmatic pneumonia; Montelukast sodium; Ambroxol; Immunoglobulin E (IgE); Curative effect·论 著·doi:10.3969/j.issn.1003-6350.2018.13.009基金项目：广东省清远市科技计划项目(编号：2014B136)