标题:2型糖尿病患者发生血管并发症的危险因素分析
作者:白慧华 1,周铸 2,邓楠 3 (武警广西总队医院内分泌科 1、普外科 2、门急诊科 3,广西 南宁 530012)
卷次:
2018年29卷13期
【摘要】 目的 分析2型糖尿病患者血管并发症的相关因素。方法 选取2016年5月至2017年5月间武警广西总队医院内分泌科诊治的100例2型糖尿病患者为研究对象,根据尿酸水平是否升高分为观察组和对照组,每组50例,收集和分析两组患者的临床资料,比较两组患者血管并发症发生情况,并采用Logistics多因素回归分析法对2型糖尿病患者发生血管并发症危险因素进行分析。结果 观察组患者的体质指数(BMI)、糖化血糖蛋白(HbA1c)、甘油三酯(TG)、胆固醇(TC)、C反应蛋白(CRP)、白介素-6 (IL-6)、肿瘤坏死因子(TNF)尿素氮(BUN)、肌酐(Cr)、收缩压(SBP)均明显高于对照组,肾小球滤过率(e-GFR)明显低于对照组,差异均有统计学意义(P<0.05);观察组患者的高血压、冠心病、脑卒中、糖尿病视网膜病变/糖尿病肾病及下肢动脉病变发生率均明显高于对照组,差异均有统计学意义(P<0.05);Logistics多因素回归分析结果显示,尿酸、病程、HbA1c、SBP为2型糖尿病患者血管并发症独立危险因素(P<0.05)。结论 高尿酸血症、病程、HbA1c、SBP是2型糖尿病患者血管并发症的独立危险因素。
【关键词】 尿酸;2型糖尿病;血管;并发症
【中图分类号】 R587.1 【文献标识码】 A 【文章编号】 1003—6350(2018)13—1802—03
Risk factors for vascular complications in patients with type 2 diabetes mellitus.
BAI Hui-hua 1, ZHOU Zhu 2, DENGNan 3. Department of Endocrinology 1, Department of General Surgery 2, Outpatient and Emergency Department 3, GuangxiGeneral Team Hospital of Armed Police Corps, Nanning 530012, Guangxi, CHINA
【Abstract】 Objective To analyze the risk factors for vascular complications in patients with type 2 diabetesmellitus Methods A total of 100 patients with type 2 diabetes from May 2016 to May 2017 in Department of Endocri-nology, Guangxi General Team Hospital of Armed Police Corps were selected and divided into observation group andcontrol group according to whether the uric acid level was elevated or not, with 50 cases in each group. The clinical datawere collected and analyzed, and the incidences of vascular complications were compared between the two groups. Lo-gistic regression analysis was used to analyze the risk factors of vascular complication in patients with type 2 diabetes.Results Body mass index (BMI), glycosylated glucose protein (HbA1c), triglyceride (TG), cholesterol (TC), C reac-tive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF), blood urea nitrogen (BUN), creatinine (Cr), systol-ic pressure (SBP) in the observation group were higher than those in the control group, and the glomerular filtration rate(e-GFR) was significantly lower than that in the control group (P<0.05). The incidence of hypertension, coronary heartdisease, stroke, diabetic retinopathy, diabetic nephropathy and lower extremity arterial disease in the observation groupwere significantly higher than those in control group (P<0.05). Logistic regression analysis showed that uric acid, dura-tion of disease, HbA1c and SBP were independent risk factors of vascular complications in type 2 diabetes mellitus (P<0.05). Conclusion Uric acid, duration of disease, HbA1c and SBP are the independent risk factors of vascular compli-cations in patients with type 2 diabetes mellitus.
【Key words】 Uric acid; Type 2 diabetes mellitus; Blood vessel; Complication·论 著·doi:10.3969/j.issn.1003-6350.2018.13.008
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