标题：高效液相色谱法在静脉麻醉药血药浓度测定中的应用

      作者：吕扬 综述 李恩有 审校    (哈尔滨医科大学附属第一医院，黑龙江 哈尔滨 150001)

      卷次： 2018年29卷11期

      【摘要】 高效液相色谱法(HPLC)是一种常用的测定血药浓度的方法，它具有灵敏度高、选择性好、定量准确等优点。HPLC法测定静脉非阿片类麻醉药(丙泊酚、咪达唑仑、依托咪酯等)、静脉阿片类麻醉药(吗啡、芬太尼、舒芬太尼等)和麻醉中的其他常用药物(顺式阿曲库铵、利多卡因等)血药浓度的结果显示，其具有较高的回收率、日内及日间精密度，适用临床血药浓度测定。
      【关键词】 高效液相色谱法；静脉麻醉药；血药浓度
      【中图分类号】 R614 【文献标识码】 A 【文章编号】 1003—6350（2018）11—1571—04

Application of high-performance liquid chromatography in the determination of blood concentration ofintravenous anesthetics.
LV Yang, LI En-you. The First Affiliated Hospital of Harbin Medical University, Harbin 150001,Heilongjiang, CHINA【Abstract】 High-performance liquid chromatography (HPLC) is a commonly used method for the determinationof plasma drug concentrations, which has the advantages of high sensitivity, good selectivity and accurate quantification.Determination by HPLC of the plasma concentration of intravenous non-opioid anesthetics (propofol, midazolam, etomi-date, etc.), intravenous opioid anesthetics (morphine, fentanyl, sufentanil, etc.) and other commonly used drugs in anes-thesia (cisatracurium, lidocaine, etc.) shows that it has a high recovery rate, intra-day and inter-day accuracy, and can beused for clinical plasma drug concentration determination.
      【Key words】 High-performance liquid chromatography (HPLC); Intravenous anesthetics; Plasma drug concentration·综 述·doi:10.3969/j.issn.1003-6350.2018.11.027