标题：系统性红斑狼疮合并骨坏死的相关临床进展

      作者：吴冰冰 1，李海燕 2，王元元 3，谢长好 1    （1.蚌埠医学院第一附属医院风湿免疫科，安徽 蚌埠 233000；2.安徽医科大学第四附属医院风湿免疫科，安徽 合肥 230000；3.蚌埠医学院第一附属医院组织与胚胎学教研室，安徽 蚌埠 233000）

      卷次： 2018年29卷11期

      【摘要】 系统性红斑狼疮(SLE)是一种累及多系统、多脏器的自身免疫性疾病，临床表现多种多样；骨坏死是在SLE的治疗过程中发病率较高的临床症状之一，发病机制复杂，目前尚未完全被阐明。本文将从疾病相关危险因素、发病机制、临床特征及诊治等多方面阐述系统性红斑狼疮合并骨坏死的相关内容。
      【关键词】 系统性红斑狼疮；骨坏死；糖皮质激素；综述
      【中图分类号】 R593.24+1 【文献标识码】 A 【文章编号】 1003—6350（2018）11—1560—04

Clinical progress of systemic lupus erythematosus combined with osteonecrosis.
WU Bing-bing 1, LI Hai-yan 2,WANG Yuan-yuan 3, XIE Chang-hao 1. 1. Department of Rheumatology, the First Affiliated Hospital of Bengbu MedicalCollege, Hefei 233000, Anhui, CHINA; 2. Department of Rheumatology, the Fourth Affiliated Hospital of Anhui MedicalUniversity, Hefei 230000, Anhui, CHINA; 3. Department of Histology and Embryology, the First Affiliated Hospital ofBengbu Medical College, Hefei 233000, Anhui, CHINA【Abstract】 Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems and multi-ple organs. The clinical manifestations are diverse. Bone necrosis is a clinical symptoms with high incidence during thetreatment of SLE, and its pathogenesis is complex and has not yet been fully elucidated. This article expounds relatedcontent of systemic lupus erythematosus combined with osteonecrosis from risk factors, the pathogenesis, the characteris-tics and the diagnosis and treatment of disease.
      【Key words】 Systemic lupus erythematosus (SLE); Osteonecrosis; Glucocorticoids; Review·综 述·doi:10.3969/j.issn.1003-6350.2018.11.024基金项目：安徽省自然科学基金面上项目(编号：1608085MH215)；安徽省高等学校省级自然科学研究重点项目(编号：KJ2016A475)；安徽省高等学校省级自然科学研究项目(编号：KJ2015B009by、KJ2013B139)