标题：诱导多能干细胞的基础及临床研究进展

      作者：杜娟，王心怡，蒋敏，刘丹，胡向阳，陈涛    (三峡大学医学院，湖北 宜昌 443002)

      卷次： 2018年29卷11期

      【摘要】 分化的体细胞经过重编程能够转化为具有多能性的干细胞，称为诱导多能干细胞(iPSCs)，它与胚胎干细胞类似，具有自我更新能力和多潜能性。iPSCs的获取不需要使用卵细胞或者胚胎细胞，因此可避免伦理上的限制。近年来 iPSCs在干细胞、表观遗传学以及生物医学领域引起了强烈的反响。本文综述了 iPSCs以及其在各系统疾病中的研究进展，以治疗和疾病建模为重点，探讨目前研究存在的挑战和机遇，为相关的临床研究提供新的指导和方向。
      【关键词】 诱导多能干细胞；重编程；治疗
      【中图分类号】 R329.2 【文献标识码】 A 【文章编号】 1003—6350（2018）11—1557—03

Basic and clinical research progress of induced pluripotent stem cells.
DU Juan, WANG Xin-yi, JIANG Min, LIU Dan,HU Xiang-yang, CHEN Tao. Medical College of Three Gorges University, Yichang 443002, Hubei, CHINA【Abstract】 Differentiated somatic cells can be reprogrammed into pluripotent stem cells, known as induced plu-ripotent stem cells (iPSCs), which have the characters of self-renewal and pluripotency. It's similar to embryonic stemcells. Avoiding the ethical restriction, the obtaining of iPSCs dose not involove the use of egg cells or embryonic cells.Recently, iPSCs has caused strong responses in the stem cells, epigenetics and biomedical research. This review summa-rizes the progress of iPSCs and its pathogenesis in various diseases, to focuses on therapeutic and disease modeling, anddiscusses the challenges and chances existing in current research, to provide new guidance and direction for related clini-cal research.
      【Key words】 Induced pluripotent stem cells (iPSCs); Reprogramming; Therapy·综 述·doi:10.3969/j.issn.1003-6350.2018.11.023基金项目：国家自然科学基金(编号：81573659)