标题：长链非编码RNA HOTAIR参与肿瘤转移的研究进展

      作者：刘浩，马俊，李涛    (广东医科大学广东省医学分子诊断重点实验室，广东 东莞 523808)

      卷次： 2018年29卷8期

      【摘要】 肿瘤转移是肿瘤患者致死的重要因素之一，大多数肿瘤患者的治疗目标就是阻断肿瘤转移，从而改善治疗效果。但现阶段人类对于肿瘤转移的控制并不理想，主要是因为对肿瘤转移的机制还了解不全面。而LncRNA近几年不断被证明其空间结构、表达水平与结合蛋白相互作用的异常与肿瘤的产生和转移有着密不可分的关联。其中HOTAIR作为一个已被发现的重要的具有反式转录调控作用的长链非编码RNA，其表达的差异对部分肿瘤的转移有着重要的调控作用。本文就近几年HOTAIR参与肿瘤转移的研究进展进行综述。
      【关键词】 长链非编码RNA；HOX转录反义RNA；肿瘤转移
      【中图分类号】 R73-37 【文献标识码】 A 【文章编号】 1003—6350（2018）08—1133—03

LncRNA HOTAIR in tumor metastasis.
LIU Hao, MA Jun, LI Tao. Guangdong Provincial Key Laboratory of MedicalMolecular Diagnostics, Guangdong Medical University, Dongguan 523808, Guangdong, CHINA【Abstract】 Tumor metastasis is an important factor for tumor patients’mortality. The main therapeutic purpose forcancer patients are to block tumor metastasis and improve patient's treatment outcome. In present, the results for tumor me-tastasis controlling is still unsatisfied, and the main reason for this situation is the poor understanding of tumor metastasismechanism. In recent years, it has been proved that the spatial structure and expression level, and the abnormality of bind-ing protein interaction of RNA are closely related to the generation and metastasis of tumors. HOX antisense intergenicRNA (HOTAIR), an important lncRNA with trans transcription regulation function, has been found having importantly regu-lation activity in tumor metastasis. In this article, we reviewed the most recent achievement for HOTAIR in tumor metastasis.
      【Key words】 Long non-coding RNA (lncRNA); HOX antisense intergenic RNA (HOTAIR); Tumor metastasis·综 述·doi:10.3969/j.issn.1003-6350.2018.08.028