标题：双歧杆菌四联活菌在防治低出生体重早产儿喂养不耐受中的应用价值

      作者：孔燕珊 1，余丰 2    (佛山市妇幼保健院新生儿科 1、检验科 2，广东 佛山 528000)

      卷次： 2018年29卷7期

      【摘要】 目的 探讨双歧杆菌四联活菌在防治低出生体重早产儿喂养不耐受中的应用价值。方法 选择佛山市妇幼保健院新生儿科2016年1~12月期间收治的60例低出生体重早产儿为研究对象，根据随机数表法将其分为观察组和对照组，每组30例，对照组给予常规治疗，观察组联合应用双歧杆菌四联活菌片治疗，疗程均为14 d。比较两组患儿的临床疗效指标及喂养不耐受、坏死性小肠结肠炎(NEC)发生率。结果 观察组患儿恢复出生体重时间、达全胃肠道营养时间、住院时间分别为(6.45±1.57) d、(8.07±1.43) d、(13.83±2.62) d，均明显短于对照组的(7.74±2.38) d、(9.28±1.75) d、(15.91±2.95) d，喂养不耐受发生率为13.33%，明显低于对照组的36.67%，差异均有统计学意义(P<0.05)；两组患儿的NEC发生率比较差异无统计学意义(P>0.05)。结论 双歧杆菌四联活菌可防治低出生体重儿早产儿的喂养不耐受、促进体重增长，缩短达到全胃肠道营养的时间及住院时间，且其应用于早产儿是安全的。
      【关键词】 双歧杆菌四联活菌；低出生体重；早产儿；喂养不耐受
      【中图分类号】 R722 【文献标识码】 A 【文章编号】 1003—6350（2018）07—1015—03

Application value of Bifidobacterium tetragenous viable bacteria in prevention of feeding intolerance in low birthweight preterm infants.
KONG Yan-shan 1, YU Feng 2. Department of Neonatology 1, Clinical Laboratory 2, Maternal andChild Health Care Hospital of Foshan, Foshan 528000, Guangdong, CHINA
【Abstract】 Objective To investigate the application value of Bifidobacterium tetragenous viable bacteria inprevention of feeding intolerance in low birth weight preterm infants. Methods A total of 60 patients of low birthweight preterm infants hospitalized in our hospital from January 2016 to December 2016 were investigated. Accordingto the random number table method, they were divided into the observation group (n=30) and the control group (n=30).The control group was treated with routine treatment, and the observation group additionally received Bifidobacterium te-tragenous viable bacteria therapy. Treatment courses in both groups were 14 days. Comparison were explored on changeof the clinical curative effect, the incidence of feeding intolerance and necrotizing enterocolitis (NEC). Results Thetime to birth weight recovery, the time to reach full enteral feedings, and hospitalization time for the observation groupwere (6.45±1.57) d, (8.07±1.43) d, (13.83±2.62) d, respectively, significantly shorter than (7.74±2.38) d, (9.28±1.75) d,(15.91±2.95) d for the control group, respectively; the incidence of feeding intolerance (13.33%) was significantly low-er than that of control group (36.67%), P<0.05. The prevalence of NEC in two groups had no statistically significantdifference (P>0.05). Conclusion The application of Bifidobacterium tetragenous viable bacteria can prevent feedingintolerance in low birth weight preterm infants, promote weight gain, shorten the time to reach full enteral feedings andhospitalization, which is safe for preterm infants.
      【Key words】 Bifidobacterium tetragenous viable bacteria; Low birth weight; Preterm infants; Feeding intolerance·临床经验·doi:10.3969/j.issn.1003-6350.2018.07.041