标题：细胞色素P450 2A13代谢外源性化学物质及其基因多态性研究进展

      作者：刘香香 1，2，吴琼 1，2，陆定艳 1，2，刘亭 1    (1.贵州医科大学贵州省药物制剂重点实验室/药用植物功效与利用国家重点实验室，贵州 贵阳 550004；2.贵州医科大学药学院，贵州 贵阳 550025)

      卷次： 2018年29卷7期

      【摘要】 细胞色素P450 (CYP)是人体代谢外源性化学物质的关键酶，参与许多前致癌物的代谢活化。细胞色素P450 2A13 (CYP2A13)是CYP家族的重要成员，主要在肺、鼻黏膜、和气管等人呼吸道组织中表达，并且参与许多前致癌物的代谢活化。许多研究表明，CYP2A13具有基因多态现象，且与肿瘤发生密切相关。本文综述了近年来CYP2A13外源性化学物质代谢和其基因多态性研究，旨在为CYP2A13的深入研究提供参考。
      【关键词】 细胞色素P450 2A13；基因多态性；代谢；研究进展
      【中图分类号】 R394.2 【文献标识码】 A 【文章编号】 1003—6350（2018）07—0972—05

Research progress on cytochrome P450 2A13 metabolic exogenous chemicals and its genetic polymorphism.
LIUXiang-xiang 1,2, WU Qiong 1,2, LU Ding-yan 1,2, LIU Ting 1. 1. Guizhou Provincial Key Laboratory of Pharmaceutics/State KeyLaboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, Guizhou,CHINA; 2. School of Pharmacy, Guizhou Medical University, Guiyang 550025, Guizhou, CHINA【Abstract】 The cytochrome P450 (CYP) enzymes are key enzymes in the metabolism of exogenous chemicalsand procarcinogens. Human CYP2A13, which is expressed in the respiratory tract, is one of the important members ofCYP family. Like other CYP450s, CYP2A13 is highly polymorphism. There is an association between the genetic varia-tion of CYP2A13 and cancer risk. In this paper, the research progress of cytochrome P450 2A13 were reviewed to pro-vide reference for the further research of CYP2A13.
      【Key words】 Cytochrome P450 2A13; Genetic polymorphism; Metabolism; Research progress·综 述·doi:10.3969/j.issn.1003-6350.2018.07.027基金项目：国家自然基金(编号：81603189)；贵阳市科技计划(联合基金)项目(编号：[20161001]03)；贵州省科学技术厅人才团队项目(编号：黔科合平台人才[2016] 5677/5613)