标题:25例Castleman病患者临床分析
作者:梁艳,熊涛,唐元艳,张利铭,黄知平 (荆州市中心医院血液内科,湖北 荆州 434020)
卷次:
2018年29卷5期
【摘要】 目的 探讨Castleman病临床表现、病理学特征、治疗及预后。方法 回顾分析2002年1月至2016年6月25例经手术切除及病理证实为Castleman病患者的临床与病理资料。结果 25例Castleman病患者中单中心型22例,其病理类型为透明血管型占81.8% (18/22);多中心型3例,病理类型为浆细胞型2例,混合型1例。25例患者均予以手术切除,中位随访时间45 (2~150)个月。22例单中心患者中21例经手术治疗后持续缓解,1例患者术后60个月复发,其病理类型为浆细胞型。结论 临床分型与病理类型影响患者预后;单中心型呈良性经过,手术治疗效果好;多中心型可出现病情进展,缺乏有效治疗方法,预后差。
【关键词】 Castleman病;临床类型;治疗;预后
【中图分类号】 R551.2 【文献标识码】 A 【文章编号】 1003—6350(2018)05—0712—03
Clinical analysis of 25 patients with Castleman disease.
LIANG Yan, XIONG Tao, TANG Yuan-yan, ZHANG Li-ming,HUANG Zhi-ping. Department of Hematology, Jingzhou Central Hospital, Jingzhou 434020, Hubei, CHINA
【Abstract】 Objective To investigate the clinicopathologic features, treatment and prognosis of Castleman disease.Methods The clinicopathologic data of 25 patients with Castleman diseases who confirmed by surgical resection and pa-thology from January 2002 to June 2016 were analyzed retrospectively. Results There were 22 unicentric cases, 81.8%(18/22) of which was hyaline-vascular types. There were 3 multicentric cases, of which two showed plasmatcyic types andone showed mixed type. All cases were treated by surgical resection, and the median follow-up was 45 (2~150) months. Af-ter treatment, 21 of the 22 unicentric cases achieved sustained remission, and one case recurred 60 months after operation,with the pathological type of plasmacyte type. Conclusion Clinical classification and histopathogenic type are the domi-nating progonostic factors in Castleman patients. The clinical presentation of unicentric disease has been found to be beg-nign and surgical resection can be used as first-line treatment method in clinic. The clinical presentation of multicentric dis-ease may be stable or advanced, and the progonosis of advanced cases is poor because of no effective treatments.
【Key words】 Castleman disease; Clinicopathologic features; Treatment; Prognosis·临床经验·doi:10.3969/j.issn.1003-6350.2018.05.039
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