标题：外周血C反应蛋白、白介素及神经递质检测对首发广泛性焦虑障碍患者记忆功能的临床意义

      作者：杨晓琴，黄霞飞，郭洪林，张富超    (攀枝花市第三人民医院心身二病区，四川 攀枝花 617061)

      卷次： 2018年29卷5期

      【摘要】 目的 研究外周血C反应蛋白(CRP)、白介素及神经递质检测对首发广泛性焦虑障碍患者记忆功能的检测临床意义。方法 选取2015年3月至2016年8月期间攀枝花市第三人民医院心身二病区收治的45例首发广泛性焦虑障碍且存在记忆功能异常患者为A组，45例首发广泛性焦虑障碍但无记忆功能异常的患者为B组，45例同龄健康人员为C组，检测并比较三组受检者的空腹外周血CRP、白介素及神经递质表达水平，同时比较A组患者中不同记忆功能状态患者的上述各项观察指标水平，采用Logistic回归分析法分析上述外周血指标与患者记忆功能的关系。结果 A组患者的外周血CRP、白介素[白介素1β (IL-1β)、IL-6、IL-8及 IL-12]及神经递质指标[5羟色胺(5-HT)、多巴胺(DA)及去甲肾上腺素(NE)]水平均高于B组及C组，B组的上述指标检测水平又高于C组，差异均有统计学意义(P<0.05)；A组患者中记忆力很差者的外周血CRP、白介素及神经递质表达水平明显高于记忆力低下者，差异均有统计学意义(P<0.05)；Logistic回归分析结果显示，上述外周血检测指标均与首发广泛性焦虑障碍患者的记忆功能有密切的关系(P<0.05)。结论 外周血CRP、白介素及神经递质对首发广泛性焦虑障碍患者记忆功能的检测临床意义较高，对患者的疾病状态尤其是记忆功能状态有积极的反映价值。
      【关键词】 外周血；C反应蛋白；白介素；神经递质；首发广泛性焦虑障碍；记忆功能
      【中图分类号】 R749.7 【文献标识码】 A 【文章编号】 1003—6350（2018）05—0606—03

Detection value of peripheral blood C-reactive protein, interleukins, and neurotransmitters for the memoryfunction of patients with generalized anxiety disorder.
YANG Xiao-qin, HUANG Xia-fei, GUO Hong-lin, ZHANGFu-chao. Second Department of Psychosomatic Diseases, the Third People's Hospital of Panzhihua City, Panzhihua 617061,Sichuan, CHINA
【Abstract】 Objective To study the detection value of peripheral blood C-reactive protein (CRP), interleukinsand neurotransmitters for the memory function of patients with generalized anxiety disorder. Methods A total of 45 pa-tients with generalized anxiety disorder and abnormal memory function from March 2015 to August 2016 in Second De-partment of Psychosomatic Diseases, the Third People's Hospital of Panzhihua City were selected as group A, 45 patientswith generalized anxiety disorder and without abnormal memory function were selected as group B, and 45 healthy per-sons of the same ages were selected as group C. The fasting peripheral blood CRP, interleukins, and neurotransmitters ofthree groups were compared, and then those indexes of group A with different memory function state before the treat-ment were compared too. The relationship between the indexes and memory function of these patients were analyzed bylogistic regression analysis. Results The peripheral blood CRP, interleukins (interleukin [IL]-1 β, IL-6, IL-8, andIL-12), and neurotransmitters (5-hydroxy tryptamine [5-HT], dopamine [DA], and norepinephrine [NE]) of group Awere all significantly higher than those of group B and group C (P<0.05), and the detection levels of group B were allsignificantly higher than those of group C (P<0.05). The peripheral blood CRP, interleukins and neurotransmitters ofgroup A with poor memory were significantly higher than those of patients with low memory (P<0.05). Logistic regres-sion analysis showed that the peripheral blood detection indexes had close relationship with the memory function ofthese patients (P<0.05). Conclusion Peripheral blood CRP, interleukins and neurotransmitters have high detection val-ue for the memory function of patients with generalized anxiety disorder, which can actively reflect for the disease state,especially the memory function state.
      【Key words】 Peripheral blood; C-reactive protein (CRP); Interleukins; Neurotransmitters; Generalized anxietydisorder; Memory function·论 著·doi:10.3969/j.issn.1003-6350.2018.05.005基金项目：四川省攀枝花市科技局科研基金(编号：2015CY-S-18-13)