标题：节律基因在结直肠癌中的研究进展

      作者：杜胜奇，蒋海涛，钟江利 综述 王红 审校    遵义医学院附属医院消化内科，贵州 遵义 563099

      卷次： 2019年30卷19期

      【摘要】 结直肠癌(CRC)在我国及世界范围内其发病率高居恶性肿瘤第三位，并呈逐渐上升趋势。近年来大量研究表明，节律基因异常表达与CRC的发生发展、治疗与预后有重要的联系。节律基因是生物钟的分子决定因素，其通过调节钟控基因(CCGs)参与多个生理过程。本文就节律基因在CRC中的表达、影响及相关机制进行综述。
      【关键词】 生物钟；节律基因；结直肠癌；相关性；机制；
      【中图分类号】 R735 【文献标识码】 A 【文章编号】 1003—6350（2019）19—2548—04

Research progress of rhythm genes in colorectal cancer.
DU Sheng-qi, JIANG Hai-tao, ZHONG Jiang-li, WANGHong. Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi 563099, Guizhou, CHINA【Abstract】 The incidence of colorectal cancer (CRC) is the third highest in malignant tumors in China and theworld, and it is gradually increasing. In recent years, a large number of studies have shown that abnormal expression ofrhythm genes is closely related to the occurrence, development, treatment and prognosis of CRC. Rhythm genes are molec-ular determinants of the biological clock and are involved in several physiological processes by regulating the clock-con-trolled genes (CCGs). This review summarizes the expression, influence and mechanism of rhythm genes in CRC.
      【Key words】 Biological clock; Rhythm genes; Colorectal cancer; Correlation; Mechanism·综述·doi:10.3969/j.issn.1003-6350.2019.19.030基金项目：贵州省科技计划课题(编号：黔科合SY字[2013]3006号)