标题：实时剪切波弹性成像技术对正常人腓肠神经硬度的初步研究

      作者：刘艳艳 1，吴贻宏 2，朱春苗 2，杨忠现 3    1.深圳市宝安区妇幼保健院超声医学科，广东 深圳 518101；2.汕头大学医学院第二附属医院超声科，广东 汕头 515041；3.汕头大学医学院第二附属医院影像中心，广东 汕头 515041

      卷次： 2019年30卷11期

      【摘要】 目的 应用实时剪切波弹性成像技术检测正常人腓肠神经硬度的变化，探讨其与性别和年龄的相关性。方法 于2017年8月至2018年7月在汕头大学医学院第二附属医院体检中心及门诊选取健康志愿者104例，将男女按照年龄分为A组(n=31，20~39岁)、B组(n=47，40~59岁)和C组(n=26，60~79岁)，利用迈瑞R7高端彩色多普勒超声诊断仪对104例健康志愿者行腓肠神经实时剪切波弹性成像检测，比较不同性别组、不同年龄组间左、右两侧腓肠神经弹性模量值之间的差异，并分析年龄与腓肠神经弹性模量值的相关性。结果 男性和女性的左侧腓肠神经弹性模量值分别为(20.80±5.37) kPa和 (20.29±6.18) kPa，右侧腓肠神经弹性模量值分别为(22.63±4.87) kPa和(22.07±6.01) kPa，男性和女性的左右两侧腓肠神经弹性模量值比较差异均无统计学意义(P>0.05)；A组、B组和C组的左侧腓肠神经弹性模量值分别为(26.49±3.72) kPa、(18.53±4.54) kPa和(16.91±3.94) kPa，右侧腓肠神经弹性模量值分别为(27.80±3.32) kPa、(20.89±4.59) kPa和(17.91±3.58) kPa，B组与A组，以及C组与A组的左右两侧腓肠神经弹性模量值比较差异均有统计学意义(P<0.01)，而C组与B组间比较则差异无统计学意义(P>0.05)；随着年龄增大，腓肠神经弹性模量值逐渐变小，且年龄与腓肠神经弹性模量值呈负相关(r=-0.78，P=0.012)。结论 不同年龄正常人的左右腓肠神经弹性模量值不同；年龄与腓肠神经弹性模量值呈负相关；实时剪切波弹性成像技术可定量评估腓肠神经的硬度变化，为进一步研究腓肠神经病变提供一定的参考价值。
      【关键词】 实时剪切波弹性成像；腓肠神经；硬度；定量分析；周围神经病变
      【中图分类号】 R746 【文献标识码】 A 【文章编号】 1003—6350（2019）11—1415—04

Application of basic research in normal sural nerve by real-time shear wave elastography.
LIU Yan-yan 1, WUYi-hong 2, ZHU Chun-miao 2, YANG Zhong-xian 3. 1. Department of Ultrasound, Baoan District Maternal and ChildHealth Hospital, Shenzhen 518101, Guangdong, CHINA; 2. Department of Ultrasound and Medical Imaging, the SecondAffiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong, CHINA; 3. Center of Imaging, theSecond Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong, CHINA
【Abstract】 Objective To investigate the hardness of the sural nerve with real-time shear wave elastic imaging,and to explore the elastic modulus of sural nerve of different genders and ages and its correlation. Methods A total of104 healthy volunteers were enrolled from the physical examination center and outpatient department of the Second Af-filiated Hospital of Shantou University Medical College from August 2017 to July 2018. Males and females were divid-ed into three groups according to age: group A (n=31, 20-39 years old), group B (n=47, 40-59 years old), group C (n=26,60-79 years old). Real-time shear wave elastography of sural nerve was performed by the high-end color of Doppler ultra-sound imaging system Miriam R7, and the differences between the left and right sural nerve elastic modulus with differentgender groups and age groups were compared. The correlation between age and the elastic modulus of sural nerve was al-so compared. Results The left sural nerve elastic modulus values of males and females were (20.80 ± 5.37) kPa and(20.29±6.18) kPa versus (22.63±4.87) kPa and (22.07±6.01) kPa, respectively; there was no statistically significant dif-ference in the elastic modulus of sural nerve between genders and ages in the left and right sides (P>0.05). The left suralnerve elastic modulus values of the group A, group B and group C were (26.49±3.72) kPa, (18.53±4.54) kPa and (16.91±3.94) kPa; and the right sacral nerve elastic modulus values were (27.80±3.32) kPa, (20.89±4.59) kPa and (17.91±3.58) kPa,respectively; there were statistically significant differences in the elastic modulus of sural nerve between group A and C,group B and C (all P<0.01), except for between group A and C (P>0.05). The elastic modulus values of the sural nervewere gradually reduced with the increase of ages. Age was negatively correlated with the elastic modulus of sural nerve(r=-0.78, P=0.012). Conclusion There were significant differences in the elastic modulus values of the sural nerveamong three groups. Age was negatively correlated with the elastic modulus values, and the elastic modulus of the suralnerve gradually decreases with age. Real-time shear wave elastography can quantitatively evaluate the changes in the hard-ness of the sural nerve and provide certain reference value for further study of the neuropathy of the sural nerve.
      【Key words】 Real-time shear wave elastography; Sural nerve; Hardness; Quantitative analysis; Peripheral neu-ropathy