标题：鼻窦球囊扩张术治疗慢性鼻-鼻窦炎有效性和安全性的荟萃分析

      作者：朱鲲鹏，白锋波    西安航天总医院耳鼻喉科，陕西 西安 710100

      卷次： 2019年30卷10期

      【摘要】 目的 系统评价鼻窦球囊扩张术(SBCD)治疗慢性鼻-鼻窦炎(CRS)的效果和手术安全性。方法 计算机检索 Pubmed、Cochrane library、Sciverse、中国知网、维普及万方数据库，检索时间截止 2018年 8月，收集所有研究 SBCD治疗CRS的随机对照试验(RCT)。由 2名研究者独立筛选文献，并使用 Revman 5.3软件进行荟萃分析。结果 共纳入 6个研究，包含 291例患者。Meta分析结果显示：SBCD术式 SNOT-20评分 [术后 3个月SMD=-0.36，95% CI (-0.98，0.26)，术后 6 个月 SMD=-0.44，95% CI (-1.84，0.95)]、Lund-Mackay 鼻窦 CT 评分[MD=-0.10，95%CI (-1.29，1.08)]、术后症状无改善情况[OR=0.70，95%CI (0.17，289)]与对照组比较差异均无统计学意义(P>0.05)。然而，SBCD组术后患者并发症发生率低于对照组，差异有统计学意义[OR=0.35，95%CI (0.15，0.79)，P=0.01]。结论 当前证据表明，SBCD治疗CRS时具有较少的术后并发症，且能够取得同传统方法相当的治疗效果，值得临床推广。
      【关键词】 鼻窦球囊扩张术；慢性鼻-鼻窦炎；荟萃分析；鼻窦疾病；鼻内镜手术
      【中图分类号】 R765.4+1 【文献标识码】 A 【文章编号】 1003—6350（2019）10—1341—04

Efficacy and safety of sinus balloon catheter dilation in the management of chronic rhinosinusitis: a systematicreview and meta-analysis.
ZHU Kun-peng, BAI Feng-bo. Department of Otorhinolaryngology, Xi'an Aerospace GeneralHospital, Xi'an 710100, Shaanxi, CHINA
【Abstract】 Objective To systematically assess the efficacy and safety of sinus balloon catheter dilation(SBCD) in the management of chronic rhinosinusitis (CRS). Methods Randomized controlled trials (RCTs) regardingthe efficacy and safety of SBCD for CRS were retrieved in PubMed, Cochrane library, SciVerse, CNKI, VIP and Wan-fang database from databases establishment to Aug. 2018. According to the including and exclusion criterion, two re-viewers independently screened the trials, conducted the meta-analysis with RevMan 5.3 software. Results A total of 6RCTs were eligible for the study including 291 cases. The pooled results showed that there were no statistically differ-ence in SNOT-20 score (3 months SMD=-0.36, 95% CI [-0.98,0.26], P=0.26, 6 months SMD=-0.44, 95% CI [-1.84,0.95], P=0.53), Lund-Mackay CT score (MD=-0.10, 95%CI [-1.29,1.08], P=0.86) and rate of unchanged postoperationsymptom (OR=0.70, 95%CI [0.17, 289], P=0.62). However, SBCD had a lower rate of adverse events compared withcontrolled group (OR=0.35, 95%CI [0.15, 0.79], P=0.01). Conclusion The current evidence shows that SBCD has alower rate of complication and a same efficacy post-operation compared with the controlled group. Therefore, SBCDshould be considered as a preferable option for CRS.
      【Key words】 Sinus balloon catheter dilation (SBCD); Chronic rhinosinusitis (CRS); Meta-analysis; Sinus dis-ease; Nasal endoscopic surgery·荟萃分析·doi:10.3969/j.issn.1003-6350.2019.10.034