标题：维生素D辅助治疗老年人社区获得性肺炎疗效观察

      作者：皮红泉 1，袁柏强 2，杨培文 2，卢盛祥 1，林启航 1    (东莞市常平医院检验科 1、呼吸科 2，广东 东莞 523573)

      卷次： 2018年29卷1期

      【摘要】 目的 探讨维生素D辅助治疗老年人社区获得性肺炎(CAP)的临床疗效。方法 选择东莞市常平医院呼吸科于2016年12月至2017年3月间收治的100例老年CAP患者为研究对象，根据随机数表法将患者分为观察组和对照组，每组50例，对照组患者予常规抗感染等治疗，观察组联合应用骨化三醇治疗，疗程为4周。比较两组患者治疗前后的血清25-羟维生素D [25-(OH)D]、超敏C反应蛋白(hs-CRP)水平及临床疗效。结果 治疗后，观察组患者的血清25-(OH)D水平为(34.22±14.63) ng/mL，明显高于对照组的(28.36±15.17) ng/mL；血清hs-CRP水平为(9.15±4.43) mg/L，明显低于对照组的(13.28±5.42) mg/L，差异均有统计学意义(P<0.05)；观察组患者的治疗总有效率为95.24%，明显高于对照组的85.71%，差异有统计学意义(P<0.05)。结论 维生素D辅助治疗老年CAP可提高体内维生素D水平，降低炎症反应程度，提高临床疗效。
      【关键词】 维生素D；老年；社区获得性肺炎；超敏C反应蛋白；疗效
      【中图分类号】 R563.1 【文献标识码】 A 【文章编号】 1003—6350（2018）01—0022—03

Clinical efficacy of vitamin D in the adjuvant treatment of elderly patients with community acquired pneumonia.PI Hong-quan 1, YUAN Bai-qiang 2, YANG Pei-wen 2, LU Sheng-xiang 1, LIN Qi-hang 1.
Department of Clinical Laboratory 1,Respiratory Department 2, Dongguan Changping Hospital, Dongguan 523573, Guangdong, CHINA
【Abstract】 Objective To investigate the clinical efficacy of vitamin D in the treatment of elderly patients withcommunity acquired pneumonia (CAP). Methods A total of 100 elderly patients with CAP treated in Respiratory De-partment, Dongguan Changping Hospital from December 2016 to March 2017 were selected and divided into observa-tion group and control group according to the random number table, with 50 cases in each group. The control groupwas treated with routine anti-infection treatment, and the observation group was treated with calcitriol, both for 4weeks. The changes of serum 25-(OH)D and hypersensitive C-reactive protein (hs-CRP) levels were compared be-tween the two groups before and after treatment, as well as the clinical efficacy. Results After treatment, the serum25-(OH)D level was (34.22±14.63) ng/mL, significantly higher than (28.36±15.17) ng/mL in the control group (P<0.05); the serum hs-CRP was (9.15±4.43) mg/L, significantly lower than (13.28±5.42) mg/L in the control group (P<0.05); the total efficiency of the observation group was 95.24%, significantly higher than 85.71% in the control group(P<0.05). Conclusion Adjuvant treatment with vitamin D can improve the vitamin D level in elderly CAP patients, re-duce the inflammatory reaction and improve the clinical efficacy.
      【Key words】 Vitamin D; Elderly; Community acquired pneumonia (CAP); Hypersensitive C reactive protein(hs-CRP)·论 著·doi:10.3969/j.issn.1003-6350.2018.02.007基金项目：广东省东莞市社会科技发展项目(编号：201650715001463)