标题：维持性血液透析患者生活质量与营养不良和微炎症的相关性

      作者：许宝珠，黄春霞，林花兰，吴福杉，吴述洪    (中国人民解放军第180医院肾脏风湿科，福建 泉州 362000)

      卷次： 2017年28卷24期

      【摘要】 目的 探讨维持性血液透析(MHD)患者生活质量与营养不良和微炎症状态的关系。方法 选择解放军第 180医院 2015年 4月至 2016年 10月期间治疗的 70例MHD患者为研究对象，检测血清超敏C反应蛋白(hs-CRP)水平并调查改良定量主观整体评估表(MQSGA)评分、SF-36量表评分，分析血清hs-CRP和MQSGA评分与 SF-36量表评分的关系。结果 70例MHD患者中营养不良者 26例，正常营养者 44例，营养不良发生率为37.14%，hs-CRP≥8 mg/L者32例，hs-CRP<8 mg/L者38例，微炎症状态发生率为45.71%；营养不良组患者SF-36量表PCS、MCS及综合评分分别为(53.18±6.24)分、(52.25±5.29)分、(55.04±4.63)分，均明显低于正常营养组的(56.89±8.37)分、(55.69±6.72)分、(58.24±6.92)分，差异均有统计学意义(P<0.05)；hs-CRP≥8 mg/L组患者PCS、MCS及综合评分分别为(53.28±8.39)分、(54.06±6.59)分、(54.97±7.68)分，均明显低于 hs-CRP<8 mg/L组的(57.74±9.46)分、(58.13±8.43)分、(58.12±9.37)分，差异均有统计学意义(P<0.05)；Spearman相关分析显示，MQSGA与SF-36量表评分呈正相关性(r=0.348，P<0.05)，hs-CRP则与SF-36量表评分呈负相关性(r=-0.359，P<0.05)。结论 MHD患者营养不良及微炎症状态的发生率较高，且与患者的生活质量关系密切。
      【关键词】 血液透析；生活质量；营养不良；微炎症；相关性
      【中图分类号】 R459.5 【文献标识码】 A 【文章编号】 1003—6350（2017）24—3990—03

Relationship between quality of life and malnutrition and micro inflammation in maintenance hemodialysispatients.
XU Bao-zhu, HUANG Chun-xia, LIN Hua-lan, WU Fu-shan, WU Shu-hong. Department of Rheumatism, the180th Hospital of Chinese PLA, Quanzhou 362000, Fujian, CHINA
【Abstract】 Objective To investigate the relationship between quality of life with malnutrition and micro in-flammatory status in patients with maintenance hemodialysis (MHD) patients. Methods A total of 70 patients withMHD, who admitted to the 180th Hospital of Chinese PLA from April 2015 to October 2016, were selected as the re-search objects. The levels of serum high sensitivity C reactive protein (hs-CRP) were detected and the modified quanti-tative subjective global assessment scale (MQSGA) score and SF-36 score were investigated in these patients, and therelationships between serum hs-CRP and MQSGA score with SF-36 score were analyzed. Results There were 26 cas-es of malnutrition and 44 cases of normal nutrition in 70 cases of MHD patients, with the malnutrition rate of 37.14%;hs-CRP≥8 mg/L group included 32 cases, and hs-CRP < 8 mg/L included 38 cases, with microinflammatory state rateof 45.71% ; the PCS, MCS and SF-36 comprehensive scores in the malnutrition group were (53.18 ± 6.24), (52.25 ±5.29), (55.04 ± 4.63), respectively, which were significantly lower than corresponding (56.89 ± 8.37), (55.69 ± 6.72),(58.24±6.92) in the normal nutrition group (P<0.05); the PCS, MCS and SF-36 comprehensive scores in hs-CRP≥8 mg/L group were (53.28±8.39), (54.06±6.59), (54.97±7.68), respectively, which were significantly lower than corre-·论 著·doi:10.3969/j.issn.1003-6350.2017.24.010基金项目：福建省泉州市科技计划项目(编号：Z[2015]0101)