标题：鼻咽癌EGFL7的表达与肿瘤侵袭转移的关系

      作者：陈顺金 1，陈靖 2，吴笑英 1，黎润球 1
    (东莞市人民医院耳鼻喉科 1、病理科 2，广东 东莞 523000 )

      卷次： 2016年27卷16期

      【摘要】 目的 检测鼻咽癌表皮生长因子样结构域7 (EGFL7)的表达水平，并观察其与肿瘤侵袭转移的相关
性，为临床诊疗提供依据。方法 选取2014年1月至2016年1月我院收治的鼻咽癌患者50例为观察组，同期鼻咽
炎患者 50例为对照组，应用免疫组化分析法检测两组患者的EGFL7表达水平、微血管密度(MVD)和淋巴管密度
(LVD)，并分析EGFL7与病理特征、MVD和LVD的关系。结果 观察组患者的EGFL7高表达率为38.0% (19/50)，
显著高于对照组的10.0% (5/50)，差异具有统计学意义(P<0.05)；EGFL7与年龄、性别和EB病毒无关(P>0.05)，与临
床分期和淋巴结转移有关(P<0.05)；EGFL7与MVD呈正相关(P<0.05)，与LVD无相关(P>0.05)。结论 EGFL7与
鼻咽癌转移有关，与血管形成有关，与淋巴管形成无关。

      【关键词】 表皮生长因子样结构域7；鼻咽癌；鼻咽炎；相关性

      【中图分类号】 R739.63 【文献标识码】 A 【文章编号】 1003—6350（2016）16—2618—03


Expression of EGFL7 in nasopharyngeal carcinoma and its relationship with tumor invasion and metastasis.
CHEN Shun-jin 1, CHEN Jing 2, WU Xiao-ying 1, LI Run-qiu 1.
Department of ENT 1, Department of Pathology 2, Dongguan
People's Hospital, Dongguan 523000, Guangdong, CHINA

【Abstract】 Objective To detect the expression of epidermal growth factor like domain 7 (EGFL7) in nasopha-
ryngeal carcinoma, and to observe its correlation with tumor invasion and metastasis, in order to provide the basis for
clinical diagnosis and treatment. Methods Fifty patients with nasopharyngeal carcinoma in our hospital were selected
as observation group from January 2014 to January 2016. Fifty patients with nasopharyngitis of the same period were se-
lected as the control group. The expression levels of EGFL7, microvessel density (MVD) and lymphatic vessel density
(LVD) of two groups were detected using immunohistochemical analysis, and the relationship between EGFL7 and
pathologic features, MVD and LVD were observed. Results The high expression rate of EGFL7 in the observation
group was 38.0% (19/50), significantly higher than 10.0% (5/50) in the control group, and the difference was statistically
significant (P<0.05). EGFL7 had nothing to do with age, sex and EB virus (P>0.05), but was associated with clinical
stage and lymph node metastasis (P<0.05). EGFL7 and MVD were positively correlated (P<0.05), and there was no cor-
relation between EGFL7 and LVD (P>0.05). Conclusion EGFL7 is related to the metastasis of nasopharyngeal carcino-
ma and the formation of blood vessels, but not correlated to the formation of lymphatic vessels.

      【Key words】 Epidermal growth factor like domain 7 (EGFL7); Nasopharyngeal carcinoma; Nasopharyngitis；Re-
lationship
·论 著·
6350.2016.16.013