标题：肝动脉化疗栓塞术联合复方斑蝥治疗中晚期原发性肝癌疗效和安全性的Meta分析

      作者：代想成，周园红，周晓琳，刘强    (宜昌市中心人民医院感染性疾病科，湖北 宜昌 443003)

      卷次： 2017年28卷21期

      【摘要】 目的 探讨肝动脉化疗栓塞（TACE）联合复方斑蝥与单纯TACE治疗中晚期原发性肝癌(APLC)的有效性和安全性。方法 检索《万方》、《知网》、《维普》、医学文献检索等中外文数据库从建库至2016年12月前发表的采用TACE联合复方斑蝥方案治疗APLC的随机对照研究（RCT），提取数据评价研究质量，并纳入Meta分析(RevMan5.3)。结果 共纳入 8篇相关文献，共含 720例APLC患者(联合组 369例，TACE组 351例)。结果表明与TACE相比，联合组能够提高APLC患者的近期有效率(OR=1.53，95%CI：1.13~2.08)和生活质量(OR=2.47，95%CI：1.61~3.79)；且能减缓疾病进展率(OR=0.27，95%CI：0.19~0.42)和减少骨髓抑制的发生率(OR=0.27，95%CI：0.19~0.42)。结论 TACE联合复方斑蝥方案对APLC患者治疗的有效性和安全性优于单纯TACE治疗。
      【关键词】 复方斑蝥；肝动脉化疗栓塞；原发性肝癌；Meta分析
      【中图分类号】 R735.7 【文献标识码】 A 【文章编号】 1003—6350（2017）21—3576—04

Safety and efficacy of transcatheter arterial chemoembolization combined with Fufangbanmao for the treatmentof advanced primary liver cancer: a meta-analysis.
DAI Xiang-cheng, ZHOU Yuan-hong, ZHOU Xiao-lin, LIUQiang. Department of Infectious Diseases, People's Hospital of Yichang Center, Yichang 443003, Hubei, CHINA
【Abstract】 Objective To evaluate the safety and the efficacy of trancatheter arterial chemoembolization(TACE) combined with Fufangbanmao compared with TACE alone for the treatment of advanced primary liver cancer(APLC) by meta-analysis. Methods The randomized controlled trials associated with the combination-treatment of Fu-fangbanmiao and TACE for APLC from the building of each database to December 2016 were searched and analyzedfrom Wangfang, CNKI, VIP and Pubmed databases. After the qualities of the included studies were assessed, meta-analy-ses were conducted by RevMan5.3 statistical software. Results Eight eligible trials were included, and a total of 720cases (369 cases from Fufangbanmiao combined with TACE treatment group and 351 cases from TACE alone treatmentgroup) were assessed in this meta-analysis. The results showed that the combination-treatment, compared with TACEalone, could increase the effective rate (OR=1.53, 95% CI: 1.13-2.08), improve the life quality (OR=2.47, 95% CI:1.61-3.79), decrease disease progression rate (OR=0.27, 95% CI: 0.19-0.42), and decreased the incident for bone mar-row suppression (OR=0.27, 95%CI: 0.18-0.40) for patients. Conclusion Meta-analysis indicates that the safety and ef-ficacy of the Fufangbanmiao combined with TACE is superior to TACE alone in the treatment of APLC.
      【Key words】 Fufangbanmao; Trancatheter arterial chemoembolization (TACE); Advanced primary liver carcino-ma (APLC); Meta-analysis·荟萃分析·doi:10.3969/j.issn.1003-6350.2017.21.045基金项目：国家自然基金青年项目（编号：81403163）；宜昌市科技攻关项目（编号：A14301-10）