标题：18F-氟化钠 PET/CT显像对骨转移瘤的诊断价值

      作者：卢乔苗，代文莉，崔邦平    (三峡大学第一临床医学院，宜昌市中心人民医院，宜昌市核医学分子影像重点实验室，湖北 宜昌 443003)

      卷次： 2017年28卷21期

      【摘要】 骨是许多恶性肿瘤远处转移好发的部位，有无骨转移对肿瘤分期、确定治疗方案和预后判断十分重要，尽早发现、合理治疗可以显著改善患者的生存质量。18F-氟化钠(18F-NaF)PET/CT因其亲骨特性和同时获得病灶解剖信息及代谢情况的优势，可以提供多元、直观的诊断信息，是骨转移瘤诊断和治疗监测的一种良好手段。骨转移最常见的原发肿瘤为前列腺癌、肺癌、乳腺癌、肾癌等，本文以这几种原发肿瘤为例，对 18F-氟化钠(18F-NaF)PET/CT显像的骨转移瘤诊断价值加以综述。
      【关键词】 骨转移瘤；PET/CT；18F-氟化钠
      【中图分类号】 R738.1 【文献标识码】 A 【文章编号】 1003—6350（2017）21—3536—04

18F-NaF PET/CT in the evaluation of skeletal metastasis.
LU Qiao-miao, DAI Wen-li, CUI Bang-ping. the FirstCollege of Clinical Medical Science, China Three Gorges University. Yichang Central People's Hospital. Yichang City KeyLaboratory of Nuclear Medicine and Molecular Imaging, Yichang 443003, Hubei, CHINA【Abstract】 Bone is a predilection site of metastasis of many malignant tumors, and detecting skeletal metastasesis important in tumor staging, determining the appropriate therapy strategy and prognosis, which may improve the lifequality of the patients. 18F-NaF positron emission and computer tomography (PET/CT) can provide multiple and intuitivediagnostic information because of its favorable bone seeking pharmacokinetics and the advantages of obtaining anatomi-cal information and metabolism. It is a good method for the diagnosis and treatment of bone metastases. This articlemainly introduces the utility and progress of 18F-NaF PET/CT in the evaluation of skeletal metastasis.
      【Key words】 Skeletal metastasis; Positron emission and computer tomography (PET/CT); 18F-NaF·综 述·doi:10.3969/j.issn.1003-6350.2017.21.030