标题：Rab蛋白在肿瘤发生发展中的作用

      作者：夏晓洁，季斌    (南通大学医学院，江苏 南通 226000)

      卷次： 2017年28卷20期

      【摘要】 Rab蛋白属于小G蛋白，是Ras超家族中的成员，目前已发现70余种。它们特异性地定位于亚细胞器中并且对胞内蛋白质的囊泡转运起着重要作用。快速的单克隆性增殖与血管淋巴结转移是恶性肿瘤难以控制的生物学因素，与肿瘤患者的预后息息相关。目前的研究已发现许多Rab蛋白在癌细胞中表达失调并且影响了癌细胞的增殖，转移能力，降低了患者的生存预后。因此本文就 Rab 蛋白在肿瘤发生发展中的研究进展做一综述。
      【关键词】 Rab蛋白；肿瘤；增殖；转移；预后
      【中图分类号】 R730.2 【文献标识码】 A 【文章编号】 1003—6350（2017）20—3368—04

Research progress of rab protein in the development of tumorigenesis.
XIA Xiao-jie, JI Bin. School of MedicineSciences, Nantong University, Nantong 226000, Jiangsu, CHINA【Abstract】 Rab protein belongs to the small G protein, is a member of the Ras super family, now has foundmore than seventy species. They are specifically localized in subcellular organelles and play an important role in vesicletransport of intracellular proteins. Rapid monoclonal proliferation and blood vessels, lymph node metastasis are the bio-logical factors of malignant tumors that is difficult to control and closely related to the prognosis of cancer patients. Thecurrent study has found that many Rab proteins have disorder expression in tumor cell and affect the proliferation andmetastasis ability of cancer cells, reducing the survival prognosis of patients. In this paper, the research progress of Rabprotein in cancer were reviewed.
      【Key words】 Rab GTPases; Tumor; Proliferation; Migration; Prognosisdoi:10.3969/j.issn.1003-6350.2017.20.032