标题：益生菌在幽门螺杆菌根除治疗中的应用进展

      作者：周义，李昌平    (西南医科大学附属医院消化内科，四川 泸州 646000)

      卷次： 2017年28卷20期

      【摘要】 幽门螺杆菌(H. pylori)感染与消化性溃疡、慢性胃炎、胃癌、胃黏膜相关淋巴组织淋巴瘤(mucosa-as-so-ciated lymphoid tissue，MALT)等疾病相关。目前有多种治疗方法，但随着抗生素耐药率的增加及药物不良反应的出现，研究者们迫切希望找到新的治疗方案。研究显示益生菌辅助治疗幽门螺杆菌感染可以提高根除率、降低抗生素不良反应发生率，这为根除幽门螺杆菌感染提供了新思路。本文就益生菌根除幽门螺杆菌感染可能的机制及研究进展做一综述。
      【关键词】 幽门螺杆菌；益生菌；治疗机制；不良反应
      【中图分类号】 R378.2 【文献标识码】 A 【文章编号】 1003—6350（2017）20—3364—04

Advances in application of probiotics in eradication of Helicobacter pylori.
ZHOU Yi, LI Chang-ping. Department ofGastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, CHINA【Abstract】 Infection with Helicobacter pylori (H. pylori) has been reported to be associated with several diseases,such as peptic ulcer, chronic gastritis, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lympho-ma. Currently, there were many therapeutic regimens for H. pylori eradication. However, because of the increase of antibi-otic resistance and occurrence of adverse drug reactions, the researchers are eager to find new treatments. Studiesshowed that probiotics as an adjuvant may improve the eradication rate and reduce side-effects of the antibiotics, whichprovide a new way of thinking for the eradication of Helicobacter pylori infection. This article reviewed the advances instudy and mechanism on application of probiotics in eradication of H. pylori．
      【Key words】 Helicobacter pylori; Probiotics; Therapy mechanism; Adverse effect·综 述·doi:10.3969/j.issn.1003-6350.2017.20.031