标题：彩色多普勒超声血流阻力指数联合血清CA125测定在卵巢肿瘤诊断中的应用价值

      作者：冯桂婷 1，王莹 1，徐玥 1，王蕾 2    (深圳市宝安区人民医院超声科 1，妇科 2，广东 深圳 518000)

      卷次： 2017年28卷20期

      【摘要】 目的 分析彩色多普勒超声血流阻力指数(RI)联合血清癌抗原125 (CA125)测定在卵巢肿瘤诊断中的应用价值。方法 选取2012年11月至2016年11月间于深圳市宝安区人民医院妇科接受手术治疗的卵巢肿瘤患者90例为研究对象，均接受超声及血清CA125检查，比较卵巢良恶性肿瘤患者RI、中心血流及血清CA125的差异。以手术病理结果为金标准，分析和比较超声RI、血清CA125检查对卵巢良恶性肿瘤的诊断效力。结果 卵巢恶性肿瘤RI为(0.41±0.12)，明显低于卵巢良性肿瘤的(0.62±0.16)，存在中心血流的比例为 53.3%，明显高于卵巢良性肿瘤的31.1%，差异均有统计学意义(P<0.05)。卵巢恶性肿瘤CA125水平为(546.5±192.3) U/mL，明显高于卵巢良性肿瘤的(28.7±14.3) U/mL，差异有统计学意义(P<0.05)。单独应用超声RI、血清CA125对卵巢良恶性肿瘤诊断敏感性、特异性等均低于85%。两者联合应用诊断效力提高，诊断敏感性、特异性、阳性预测值、阴性预测值及诊断符合率分别达88.9%、91.1%、90.9%、89.1%及90.0%。结论 超声RI、血清CA125对卵巢良恶性肿瘤的鉴别诊断具有较高的应用价值，联合应用可以提高诊断效力。
      【关键词】 超声；卵巢；阻力指数；癌抗原125；卵巢肿瘤
      【中图分类号】 R737.31 【文献标识码】 A 【文章编号】 1003—6350（2017）20—3346—03

Application value of resistance index in color Doppler ultrasound combined with serum CA125 in the diagnosis ofovarian tumors.
FENG Gui-ting 1, WANG Ying 1, XU Yue 1, WANG Lei 2. Department of Ultrasonography 1, Department ofGynaecology 2, People's Hospital of Baoan District of Shenzhen, Shenzhen 518000, Guangdong, CHINA
【Abstract】 Objective To evaluate the value of resistance index (RI) in color Doppler ultrasound combinedwith serum cancer antigen 125 (CA125) in the diagnosis of ovarian tumors. Methods Ninety patients of ovarian cancerwho received surgical treatment in People's Hospital of Baoan District of Shenzhen from Nov. 2012 to Nov. 2016 wereselected as the research objects, which all underwent ultrasonography and serum CA125 detection. RI, central bloodflow and serum CA125 levels in patients with benign and malignant ovarian tumors were compared. The diagnostic effi-cacy of RI and serum CA125 in the diagnosis of benign and malignant ovarian tumors were analyzed and compared, tak-ing pathological findings as golden standard. Results The RI and the proportion of central blood flow in malignantovarian tumors were (0.41±0.12) and 53.3%, versus (0.62±0.16) and 31.1% in benign ovarian tumors (P<0.05). The lev-el of CA125 in malignant ovarian tumors was (546.5±192.3) U/mL, significantly higher than (28.7±14.3) U/mL of be-nign ovarian tumors (P<0.05). The sensitivity and specificity of RI and serum CA125 in the diagnosis of benign and ma-lignant ovarian tumors were all lower than 85%, but the diagnostic efficacy of combined application of the two methodswas improved, with the diagnostic sensitivity, specificity, positive predictive value, negative predictive value and diag-nostic coincidence rate of 88.9%, 91.1%, 90.9%, 89.1%, 90.0%, respectively. Conclusion RI and CA125 have high val-ue in the diagnosis of benign and malignant ovarian tumors, and combined application of the two can improve the diag-nostic effectiveness.
      【Key words】 Ultrasound; Ovary; Resistance index; Cancer antigen 125 (CA125); Ovarian tumors·论 著·doi:10.3969/j.issn.1003-6350.2017.20.026