标题：磺胺嘧啶银联合芦荟烧伤膏对糖尿病大鼠末梢循环障碍及足溃疡的保护作用

      作者：赵跃萍 1，张博 2，刘美君 1，侯雨杉 2，孙萌萌 1，李清 1，袁菲阳 1，苏红 1，邰贺 1    (武警辽宁省总队医院内分泌与代谢病科 1、烧伤整形科 2，辽宁 沈阳 110034)

      卷次： 2017年28卷19期

      【摘要】 目的 研究磺胺嘧啶银联合芦荟烧伤膏对糖尿病大鼠足溃疡的保护作用并探讨其机制。方法 选取清洁级性成熟Wistar大鼠90只制成糖尿病大鼠模型，将成功造模的80只大鼠按照随机数表法分为末梢循环障碍模型组与足溃疡模型组，每组均40只。成功造模且符合研究要求的末梢循环障碍模型组(n=35)按照随机数表法分为对照组(n=18)与观察组(n=17)，足溃疡模型组(n=36)按照随机数表法分为对照组(n=18)与观察组(n=18)，所有大鼠均给予磺胺嘧啶涂抹患处，观察组在此基础上给予芦荟烧伤膏，连续给药35 d，治疗期间(1周、2周、3周)记录末梢循环障碍大鼠足底皮温、疼痛阈值，记录足溃疡大鼠溃疡面愈合情况及其外周血清血管内皮生长因子(VEGF)。结果 末梢循环障碍模型组大鼠治疗过程中各个时间点观察组的足底温度高于对照组，而疼痛阈值低于对照组，且差异有统计学意义(P<0.05)。足溃疡模型组大鼠治疗过程中各个时间点比较观察组溃疡愈合率、外周血清血管内皮生长因子(VEGF)均高于对照组，且差异有统计学意义(P<0.05)。结论 磺胺嘧啶银联合芦荟烧伤膏能很好地改善糖尿病大鼠的末梢循环引起的温度及痛觉迟钝，与此同时能通过提高VEGF的表达促进足溃疡大鼠溃疡面愈合。
      【关键词】 糖尿病足；溃疡；末梢循环障碍；血管内皮生长因子；磺胺嘧啶银；芦荟烧伤膏
      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2017）19—3102—04

A study of silver sulfadiazine combined with aloes burn cream in the protection of peripheral curculatorydiaorders and ulcer on diabetic foot in diabetic rat.
ZHAO Yue-ping 1, ZHANG Bo 2, LIU Mei-jun 1, HOU Yu-shan 2,SUN Meng-meng 1, LI Qing 1, YUAN Fei-yang 1, SU Hong 1, TAI He 1. Department of Endocrinology and Metabolic Disease 1,Department of Burns and Plastic Surgery 2, Liaoning Provincial Corps Hospital of Chinese People's Armed Police Forces,Shenyang 110034, Liangning, CHINA
【Abstract】 Objective To study the mechanism of silver sulfadiazine combined with aloes burn cream in theprotection of peripheral curculatory diaorders and ulcer on diabetic foot in diabetic rats. Methods A total of 80 model-ing diabetic viripotent Wistar rats (modeled from 90 rats) were divided into the mold of peripheral curculatory diaordersgroup and the ulcer group according to random number tables, with 40 rats in each group. The peripheral curculatory di-aorders group received an ice-cold stimulation, and 35 rats were successful, which were divided into the control group(silver sulfadiazine, n=18) and the observation group (silver sulfadiazine + aloes burn cream, n=17) randomly and re-ceived different treatments (treatment course for 35 days). On post treatment day (1, 2, and 3 weeks), the plantar tempera-·论 著·doi:10.3969/j.issn.1003-6350.2017.19.003