标题：217对不良孕产史夫妇细胞遗传学分析

      作者：何淑贞，蒲育栋，曹金如，陈美玲，苏焕厚，邓汉钊，莫丽芳
    (东莞市第三人民医院产科暨产前诊断中心，广东 东莞 523326)

      卷次： 2016年27卷15期

      【摘要】 目的 探讨不良孕产史与外周血染色体核型之间的关系，为遗传咨询提供依据。方法 采集2013年
1月至2015年11月来我院就诊的217对不良孕产史患者的外周血，分别进行外周血淋巴细胞培养、制做玻片和Ｇ
显带后核型分析。结果 217对不良孕产史夫妇中共发现染色体异常的核型 9例，异常染色体核型检出率为
2.07%，多态性核型55例，检出率为12.67%。结论 染色体异常是造成患者发生不良孕产史的主要原因之一，因此
应对存在不良孕产史的夫妇常规开展细胞遗传学检查及适时的遗传咨询。

      【关键词】 核型分析；不良孕产史；多态性

      【中图分类号】 R394.2 【文献标识码】 A 【文章编号】 1003—6350（2016）15—2542—02


Cytogenetic analysis of 217 couples with adverse pregnancy history.
HE Shu-zhen, PU Yu-dong, CAO Jin-ru, CHEN
Mei-ling, SU Huan-hou, DENG Han-zhao, MO Li-fang. Obstetrics and Prenatal Diagnosis Center, the Third People's
Hospital of Dongguan, Dongguan 523326, Guangdong, CHINA

【Abstract】 Objective To investigate the relationship between abnormal pregnancy and peripheral blood karyo-
type, and provide the basis for genetic counseling. Methods The peripheral blood of 217 couples with adverse pregnan-
cy history were collected in our hospital from January 2013 to November 2015. Then the peripheral blood lymphocytes
were cultured, and karyotype analysis of G banding was carried out. Results Among 217 couples, 9 cases were found
with abnormal karyotype (with the detection rate of 2.07%), and 55 cases were found with polymorphic karyotype (with
the detection rate of 12.67%). Conclusion Chromosomal abnormality is an important reason that leads to adverse preg-
nancy history. Therefore, the couples with adverse pregnancy history should receive routine prenatal cytogenetic exami-
nation and consultation to prevent birth defects, and improve the quality of the birth service.

      【Key words】 Karyotype analysis; Adverse pregnancy history; Polymorphism
·临床经验·
6350.2016.15.046