标题：神经肌肉电刺激治疗帕金森病合并不宁腿综合征疗效观察

      作者：张露远 1，王红洲 1，潘胜桂 2，唐晴 1，张炎 1，石磊 1，鲍治诚 1    (昆山市第一人民医院脑病中心 1、康复科 2，江苏 昆山 215300)

      卷次： 2017年28卷16期

      【摘要】 目的 观察使用神经肌肉电刺激(NMES)治疗帕金森病(PD)合并不宁腿综合征(RLS)患者的临床疗效。方法 连续收集2014年1月至2016年6月就诊于昆山市第一人民医院门诊的89例确诊为PD患者，根据RLS诊断标准分为不合并RLS者66例和合并RLS者23例，计算其患病率并比较两者的起病年龄、病程、左旋多巴日用量及统一帕金森病评定量表(UPDRS)评分，将合并RLS的PD患者完全随机分为神经肌肉电刺激组 12例(NMES组)及假治疗组11例，每周治疗5次，10次为一个疗程之后使用不宁腿综合征评定量表(RLSRS)评定治疗前后两组患者的评分并进行比较。结果 本组89例患者中RLS合并PD患病率为25.84%；PD不合并RLS者病程(3.95±2.79)年、左旋多巴日用量(484±90.65) mg及UPDRS评分为(32.25±3.89)分，PD合并RLS者的病程(4.15±3.39)年、左旋多巴日用量(440±125.4) mg、UPDRS评分为(37.14±2.27)分，两组比较差异均无统计学意义(P>0.05)。PD合并RLS者中NMES组治疗前后的RLSRS评分分别为(20.15±4.56)分和(13.56±4.12)分，而假治疗组治疗前后的RLSRS分别为(23.22±3.27)分和(21.11±3.89)分，两组治疗前RLSRS评分差异无统计学意义(P>0.05)，而治疗后比较差异有显著统计学意义(P<0.01)。结论 NMES在一定程度上可以改善PD患者的不宁腿症状，提高患者的活动能力和生活质量。
      【关键词】 帕金森病；不宁腿综合征；神经肌肉电刺激；疗效
      【中图分类号】 R742.5 【文献标识码】 A 【文章编号】 1003—6350（2017）16—2619—03

Therapeutic effects of neuromuscular electric stimulation on patients with Parkinson's disease and restless legssyndrome.
ZHANG Lu-yuan 1, WANG Hong-zhou 1, PAN Sheng-gui 2, TANG Qing 1, ZHANG Yan 1, SHI Lei 1, BAOZhi-cheng 1. Department of Encephalopathy Center 1, Department of rehabilitation 2, First People's Hospital of Kunshan,Kunshan 215300, Jangsu, CHINA
【Abstract】 Objective To investigate the clinical therapeutic effects of neuromuscular electric stimulation(NMES) on patients with Parkinson's disease (PD) and restless legs syndrome (RLS). Methods A total of 89 PD outpa-tients in the First People's Hospital of Kunshan from January 2014 to June 2016 were collected and divided into 66 casesof non-combined RLS and 23 cases of combined with RLS according to RLS diagnostic criteria. The prevalence rate,age of onset, the course of disease, the dosage of levodopa, and the unified Parkinson's disease rating scale (UPDRS)score were measured and compared. The patients with PD and RLS were divided into the NMES group (n=12) and thesham group (n=11). The NMES group were treated with NMES for 5 times a week. After taking 10 times as a treatmentcourse, the two groups of patients before and after treatment were assessed and compared using Restless Leg SyndromeRating Scale (RLSRS). Results The prevalence rate of patients with RLS and PD was 25.84%. The course of disease,daily levodopa dosage, UPDRS of patients only with PD were respectively (3.95±2.79) years, (484±90.65) mg, (32.25±3.89), and those of patients with PD and RLS were respectively (4.15±3.39) years, (440±125.4) mg, (37.14±2.27), withno significant differences between them (P>0.05). The RLSRS scores of the NMES group before and after treatmentwere respectively (20.15±4.56) and (13.56±4.12), and those of the sham group before and after treatment were respec-tively (23.22±3.27) and (21.11±3.89), with no significant difference in RLSRS scores between the two groups beforetreatment (P>0.05), but significant difference between the two groups after treatment (P<0.01). Conclusion NMES iseffective in reducing RLS symptoms of patients with PD, which can significantly improve locomotor activity and qualityof life.
      【Key words】 Parkinson's disease (PD); Restless legs syndrome (RLS); Neuromuscular electrical stimulation(NMES); Therapeutic effects·论 著·doi:10.3969/j.issn.1003-6350.2017.16.012基金项目：江苏省昆山市第一人民医院脑病临床与基础研究基金（编号：KYC004）