标题：重组人白介素11治疗急性白血病化疗后血小板减少的临床疗效

      作者：胡媛媛 1，高小见 2，肖传宇 3    (枣阳市第一人民医院血液肿瘤科 1、心胸外科 2、检验科 3，湖北 枣阳 441200)

      卷次： 2017年28卷15期

      【摘要】 目的 探讨重组人白介素11治疗急性白血病化疗后血小板减少的临床疗效。方法 选取2014年1月至 2016年 1月于枣阳市第一人民医院收治的急性白血病患者 60例作为研究对象。根据随机数表法分为对照组和观察组，各 30例，对照组实施常规化疗，观察组实施常规化疗联合重组白细胞介素-11，比较两组患者血小板计数变化。结果 观察组血小板最低值[(8.7±2.0)×109/L]与对照组[(8.8±1.9)×109/L]比较差异无统计学意义(P>0.05)；血小板最高值[(162.3±30.2)×109/L]明显高于对照组[(90.6±21.7)×109/L，P<0.05]：观察组和对照组患者的血小板恢复时间[(11.9±5.2) d vs (15.6±6.0) d ]、血小板输入量[(7.1±3.1) U vs (10.7±4.2) U]、出血率[23.3% vs 63.3%]、不良反应率[13.3% vs 66.7% ]比较，观察组均明显低于或少于对照组，差异均有统计学意义(P<0.05)。结论 重组人白介素11治疗急性白血病化疗后血小板减少的临床疗效较佳，且不良反应发生率低，临床应用安全。
      【关键词】 血小板；重组人白细胞介素-11；出血量；血小板减少
      【中图分类号】 R733.71 【文献标识码】 A 【文章编号】 1003—6350（2017）15—2434—03

Clinical effect of recombinant human interleukin 11 in treating thrombocytopenia induced by chemotherapy inpatients with acute leukemia.
HU Yuan-yuan 1, GAO Xiao-jian 2, XIAO Chuan-yu 3. Department of Hematology andOncology 1, Department of Cardio-Thoracic Surgery 2, Department of Clinical Laboratory 3, the First People's Hospital ofZaoyang, Zaoyang 441200, Hubei, CHINA
【Abstract】 Objective To investigate the clinical efficacy of recombinant human interleukin 11 in treatingthrombocytopenia induced by chemotherapy in patients with acute leukemia (AL). Methods A total of 60 patients withAL in our hospital from January 2014 to January 2016 were selected as the research objects. According to the randomnumber table, they were divided into control group and observation group, with 30 patients in each group. The controlgroup received routine chemotherapy, while observation group received routine chemotherapy combined with recombi-nant interleukin-11. The changes of platelet count between the two groups were compared. Results The lowest plateletcount in observation group and control group were respectively (8.7±2.0)×109/L, and (8.8±1.9)×109/L, with no statistical-ly significant difference between the two groups (P>0.05). The highest platelet count in observation group was (162.3±30.2)×109/L, which was significantly higher than (90.6±21.7)×109/L in control group, P<0.05. The platelet recovery timein observation group was (11.9±5.2) d, which was significantly lower than (15.6±6.0) d in control group, P<0.05. The·论 著·doi:10.3969/j.issn.1003-6350.2017.15.007基金项目：湖北省卫生和计划生育委员会科研项目(编号：WJ2015Z098)