标题：中国内地医院肿瘤患者MRSA流行状况的Meta分析

      作者：李玲，叶小华，陈思东    (广东药科大学公共卫生学院，广东 广州 510310)

      卷次： 2017年28卷14期

      【摘要】 目的 综合评价中国内地医院肿瘤患者耐甲氧西林金黄色葡萄球菌(MRSA)检出率情况。方法 通过中国知网(CNKI)、万方数据库、Medline等数据库，查找发表于2015年1月至2016年1月的中国内地医院肿瘤患者MRSA检出率的相关文献。根据统一的纳入与排除标准筛选文献后，采用Stata13.0统计软件进行Meta分析。结果 检索到104篇文献，符合标准14篇。医院肿瘤患者MRSA合并检出率为39.00% (25.00%~53.00%)。中国南、北地区医院肿瘤患者MRSA合并检出率分别为34.00% (13.00%~55.00%)和45.00% (29.00%~61.00%)，南北方不同地理位置差异具有统计学意义(P<0.05)。东、中、西部经济区域医院肿瘤患者MRSA合并检出率分别为 40.00%(21.00%~59.00%)、32.00% (29.00%~61.00%)、34.00 (18.00%~86.00%)，在各经济区域之间进行比较，差异均无统计学意义(P>0.10)。结论 中国内地医院肿瘤患者MRSA的检出率较高，是影响肿瘤患者预后和生存的重要因素，应加强肿瘤患者MRSA的监测，降低肿瘤患者MRSA感染的发生率。
      【关键词】 肿瘤患者；金黄色葡萄球菌；耐甲氧西林；检出率；Meta分析
      【中图分类号】 R73-31 【文献标识码】 A 【文章编号】 1003—6350（2017）14—2383—04

Detection rate of methicillin-resistant Staphylococcus aureus in cancer patients in Chinese hospital: ameta-analysis.
LI Ling, YE Xiao-hua, CHEN Si-dong. School of Public Health, Guangdong Pharmaceutical University,Guangzhou 510310, Guangdong, CHINA
【Abstract】 Objective To evaluate the detection rate of methicillin-resistant Staphylococcus aureus (MRSA) incancer patients in Chinese hospital by meta-analysis. Methods The related literatures of MRSA detection rate in cancerpatients in Chinese hospitals published from January 2015 to January 2016 were got by retrieving China National Knowl-edge Infrastructure (CNKI), Wanfang Medical Network and Medline databases. Stata13.0 software was used to performmeta-analysis after screening literatures based on uniform inclusion and exclusion criteria. Results A total of 104 arti-cles were retrieved, 14 of which met the criteria. The detection rates of MRSA were 39.00% (25.00%-53.00%) in cancerpatients in hospitals. The detection rates of MRSA in the north and south of China were 34.00% (13.00%-55.00%) and45.00% (29.00%-61.00%), respectively. There was statistically significant difference between the two regions (P<0.05).In the eastern, central and western economic regions, the detection rates of MRSA were 40.00% (21.00%-59.00% ),32.00% (29.00%-61.00%) and 34.00% (18.00%-86.00%), respectively. There was no significant difference in the detec-tion rates of MRSA in cancer patients in hospitals among three economic regions (P>0.10). Conclusion The detectionrate of MRSA in cancer patients in Chinses hospitals is high, which is an important factor in the prognosis and survival ofcancer patients. MRSA surveillance should be strengthened to reduce the incidence of MRSA infection in cancer patients.
      【Key words】 Cancer patients; Staphylococcus aureus; Methicillin-resistant; Detection rate; Meta-analysis·荟萃分析·doi:10.3969/j.issn.1003-6350.2017.14.050基金项目：广东省科技计划项目(编号：2014A020212306)