标题：自拟健脾理气祛瘀方改善糖耐量减低患者胰岛素抵抗的疗效观察

      作者：王国珍，曾胜，刘文豪    (梅州市中医医院内一科，广东 梅州 514011)

      卷次： 2017年28卷14期

      【摘要】 目的 探讨自拟健脾理气祛瘀方改善糖耐量减低患者胰岛素抵抗的疗效。方法 选择2014年1月至2016年1月期间梅州市中医医院内科诊治的150例糖耐量减低患者为研究对象，根据随机数表法随机分为观察组和对照组，每组75例，对照组予二甲双胍治疗，观察组联合应用自拟健脾理气祛瘀方治疗，疗程均为3个月。比较两组患者治疗前后的空腹血糖 (FPG)、餐后 2 h血糖 (2 hPG)及胰岛素抵抗指数 (HOMA-IR)、胰岛β细胞功能指数(HOMA-IS)水平。结果 治疗后，观察组和对照组患者的FPG、2 hPG、HOMA-IR分别为(5.68±0.48) mmol/L、(8.35±2.15) mmol/L、(2.46±0.62)和(6.05±0.62) mmol/L、(9.13±2.08) mmol/L、(2.91±0.57)，均较治疗前的(6.51±0.26) mmol/L、(10.48±2.68) mmol/L、(3.81±0.97)和(6.62±0.31) mmol/L、(10.53±2.49) mmol/L、(3.78±0.79)显著降低，HOMA-IS为(21.98±1.98)和(18.64±8.64)，均较治疗前的(15.39±5.39)和(16.38±6.38)显著提高，且观察组明显优于对照组，差异均有统计学意义(P<0.05)。结论 自拟健脾理气祛瘀方治疗糖耐量降低可以改善胰岛素抵抗，提高胰岛素敏感性。
      【关键词】 糖耐量减低；糖尿病；胰岛素抵抗；健脾理气祛瘀方；疗效
      【中图分类号】 R587 【文献标识码】 A 【文章编号】 1003—6350（2017）14—2352—02

Efficacy of self-designed Jianpiliqiquyufang in improving insulin resistance in patients with impaired glucosetolerance.
WANG Guo-zhen, ZENG Sheng, LIU Wen-hao. Department of Internal Medicine, Meizhou Hospital ofTraditional Chinese Medicine, Meizhou 514011, Guangdong, CHINA
【Abstract】 Objective To study the effect of self-designed Jianpiliqiquyufang in improving insulin resistance inpatients with impaired glucose tolerance status. Methods From January 2014 to January 2016, 150 patients with im-paired glucose tolerance treated in Department of Endocrinology of our hospital were selected as the research objects, ac-cording to the random number table method, which were divided into observation group (n=75) and control group (n=75). The control group was treated with metformin treatment, and the observation group received self-designed Jianpiliqiquy-ufang plus metformin treatment. The course of treatment was 3 months. Fasting plasma glucose (FPG), 2 h-postprandial plas-ma glucose (2 hPG) and insulin resistance index (HOMA-IR), islet beta cell function index (HOMA-IS) levels were com-pared between the two groups. Results After treatment, the FPG, 2 hPG, HOMA-IR, HOMA-IS respectively were (5.68±0.48) mmol/L, (8.35±2.15) mmol/L, (2.46±0.62), (21.98±1.98) in the observation group and (6.05±0.62) mmol/L, (9.13±2.08) mmol/L, (2.91±0.57), (18.64±8.64) in the control group, compared with (6.51±0.26) mmol/L, (10.48±2.68) mmol/L,(3.81±0.97), (15.39±5.39) in the observation group and (6.62±0.31) mmol/L, (10.53±2.49) mmol/L, (3.78±0.79), (16.38±6.38) in the control group before treatment. The levels in the observation group were significantly better than those in thecontrol group (P<0.05). Conclusion Self-designed Jianpiliqiquyufang can reduce insulin resistance, improve insulinsensitivity in impaired glucose tolerance.
      【Key words】 Impaired glucose tolerance; Diabetes mellitus; Insulin resistance; Jianpiliqiquyufang; Efficacy·临床经验·doi:10.3969/j.issn.1003-6350.2017.14.036基金项目：广东省中医药局科研课题(编号：20121072)