标题：DC-SIGN固有免疫调节机制的研究进展

      作者：王舒煜，王家凤，武玉凤，刘畅，张志民    (吉林大学口腔医院牙体牙髓病科，吉林 长春 130021)

      卷次： 2017年28卷14期

      【摘要】 树突状细胞(DC)是目前已知功能最强的抗原呈递细胞。它既可以激活初始免疫应答，又能够抑制免疫反应，这与其表达的多种模式识别受体有关，其中DC-SIGN是C型凝集素受体的主要成员，由于它在DC的细胞粘附、迁移、激活初始T细胞、引发免疫反应及参与病原体免疫逃逸等多个方面发挥免疫调节作用，已经成为近年来的研究热点，对其功能的研究可能会为某些疾病提供新的治疗方法，具有重要的临床意义。本文就DC-SIGN免疫调节机制的最新进展做一综述。
      【关键词】 树突状细胞；DC-SIGN；免疫调节；机制
      【中图分类号】 R392 【文献标识码】 A 【文章编号】 1003—6350（2017）14—2323—04

Advances in the study of regulation mechanisms of innate immunity of DC-SIGN.
WANG Shu-yu, WANG Jia-feng,WU Yu-feng, LIU Chang, ZHANG Zhi-min. Department of Endodontics, Stomatology Hospital, Jilin University, Changchun130021, Jilin, CHINA【Abstract】 It is well known that dendritic cells are the most potent antigen presenting cells. They can activateprimary immune response, but also downregulate immune response, which relates with a variety of pattern recognitionreceptors expressed by them. DC-SIGN (DC-specific ICAM-3-grabbing nonintegrin, CD209) is primary member of theC-type lectin receptors. In recent years, DC-SIGN has received great attention due to its important role in immunologicalregulation such as mediating cell adhesion, migration, activating primary T cells, triggering the immune response and im-mune escape of pathogens. The study of DC-SIGN can provide us with a new method in treating certain diseases and haveimportant clinical significance. This article reviews the latest advances in DC-SIGN immunoregulatory mechanisms.
      【Key words】 Dendritic cells; DC-SIGN; Immunoregulation; Mechanism·综 述·doi:10.3969/j.issn.1003-6350.2017.14.027基金项目：吉林省省级产业创新专项资金项目（编号：2016C0453）