标题：加强药物疗法联合鼻内镜手术治疗慢性鼻-鼻窦炎疗效观察

      作者：郑富春，侯勇    (安康市人民医院耳鼻喉科，陕西 安康 725000)

      卷次： 2017年28卷12期

      【摘要】 目的 观察加强药物疗法联合鼻内镜手术综合治疗慢性鼻-鼻窦炎患者的临床疗效。方法 选取2015年3月至2016年3月在我院接受治疗的慢性鼻-鼻窦炎患者86例，根据随机数表法分为观察组和对照组，每组43例，对照组患者给予加强药物治疗，疗程为12周。观察组则在对照组治疗的基础上加用鼻内镜手术治疗。比较两组患者的临床疗效，治疗前后症状情况、白细胞介素(IL-8)、肿瘤坏死因子-α (TNF-α)水平变化以及躯体症状、精神功能情况。结果 观察组患者的治疗总有效率为 93.02%，明显高于对照组的 76.74%，差异有统计学意义(P<0.05)；治疗后观察组和对照组患者的视觉模拟评分(VAS)分别为(1.3±0.3)分、(2.1±0.7)分，均明显低于治疗前，且观察组明显低于对照组，差异均有统计学意义(P<0.05)；治疗后观察组患者的 IL-8、TNF-α水平分别为(191.2±70.2) μg/L、(34.2±13.1) μg/L，均明显低于对照组的(225.6±82.5) μg/L、(40.5±11.5) μg/L，差异均有统计学意义(均P<0.05)；治疗后观察组患者躯体症状及精神功能评分分别为(3.5±1.4)分、(2.2±1.3)分，均显著低于对照组的(7.9±3.1)分、(9.8±4.6)分，差异有统计学意义(均P<0.05)。结论 加强药物疗法联合鼻内镜手术综合治疗慢性鼻-鼻窦炎的疗效显著，其可有效改善患者症状，控制炎症反应，同时显著改善其躯体症状及精神功能。
      【关键词】 鼻窦炎；药物疗法；鼻内镜手术；疗效；症状
      【中图分类号】 R765.4+1 【文献标识码】 A 【文章编号】 1003—6350（2017）12—1941—03

Clinical observation of strengthening drug therapy combined with nasal endoscopic surgery for chronic nasalsinusitis.
ZHENG Fu-chun, HOU Yong. Department of ENT, Ankang People's Hospital, Ankang 725000, Shaanxi, CHINA
【Abstract】 Objective To observe the clinical effects of strengthening drug therapy combined with nasal endo-scopic surgery in the treatment of patients with chronic nasal sinusitis. Methods A total of 86 cases of patients withchronic sinusitis, who admitted to our hospital from March 2015 to March 2016, were selected and divided into the ob-servation group and the control group according to random number table method, with 43 cases in each group. The con-trol group were given strengthening drug treatment for 12 weeks. The observation group was treated with additional na-sal endoscopic surgery based on the control group's treatment. The clinical curative effect, symptoms before and afterthe treatment situation, interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-α) level changes, physical symptoms andmental function of the two groups were compared. Results The total effective rate of the observation group was93.02%, which was significantly higher than 76.74% in the control group (P<0.05). After the treatment, the Visual Ana-logue Scale (VAS) of the observation group and the control group were respectively (1.3±0.3) points and (2.1±0.7) points,which were significantly lower than those before the treatment, and the observation group was significantly lower thanthe control group (P<0.05); the levels of IL-8 and TNF-α in the observation group were respectively (191.2±70.2) μg/Land (34.2±13.1) μg/L, which were significantly lower than (225.6±82.5) μg/L and (40.5±11.5) μg/L in the controlgroup (P<0.05); the physical symptoms and mental function score in the observation group were respectively (3.5±1.4)points and (2.2±1.3) points, which were significantly lower than (7.9±3.1) and (9.8±4.6) in the control group (P<0.05).Conclusion To strengthen the combination of drug therapy with nasal endoscopic surgery has significant curative ef-fect in the treatment of chronic nasal sinusitis, which can effectively improve the symptoms of patients, control the in-flammatory response, and significantly improve their physical symptoms and mental function.
      【Key words】 Sinusitis; Drug therapy; Nasal endoscopic surgery; Curative effect; Symptoms·论 著·doi:10.3969/j.issn.1003-6350.2017.12.016基金项目：陕西省科学技术基金（编号：2015SF131）