标题：银杏达莫注射液治疗稳定型心绞痛的疗效及其对患者血管硬度和内皮损伤标志物的影响

      作者：梁华添 1，杨震 2    (1.恩平市人民医院心血管内科，广东 恩平 529400；2.中山大学附属第一医院心血管内科，广东 广州 510080)

      卷次： 2017年28卷12期

      【摘要】 目的 探讨银杏达莫注射液治疗稳定型心绞痛的疗效及对患者血管硬度和内皮损伤标志物的影响。方法 选择我院心内科于2015年1月至2016年11月间收治的52例稳定型心绞痛患者为研究对象，根据随机数表法将患者分为观察组和对照组，每组 26例，对照组予常规抗血小板、调脂等对症治疗，观察组联合应用银杏达莫注射液治疗，疗程 2周。比较治疗前后两组患者的心绞痛每周发作次数、臂踝脉搏波速度(ba-PWV)及外周血内皮祖细胞(EPC)的含量。结果 治疗后，观察组患者的心绞痛发作次数为(2.45±0.59)次/周，明显少于对照组的(4.67±1.86)次/周，差异有统计学意义(P<0.05)；观察组患者 ba-PWV为(1 401.7±165.3) cm/s，明显低于对照组的(1 533.8±176.6) cm/s，外周血EPC为(0.027±0.011)%，明显高于对照组的(0.019±0.009)%，差异均有统计学意义(P<0.05)。结论 银杏达莫注射液应用于稳定型心绞痛的治疗可以有效改善患者的血管僵硬度、提高内皮祖细胞的数量，从而提高临床疗效。
      【关键词】 银杏达莫注射液；稳定型心绞痛；血管僵硬度；内皮祖细胞
      【中图分类号】 R541.4 【文献标识码】 A 【文章编号】 1003—6350（2017）12—1911—03

Curative effect of Yinxing Damo injection in the treatment of stable angina pectoris and effect on vascularstiffness and endothelial injury markers.
LIANG Hua-tian 1, YANG Zhen 2. 1. Department of Cardiovascular Medicine,Enping People's Hospital, Enping 529400, Guangdong, CHINA; 2. Department of Cardiovascular Medicine, the FirstAffiliated Hospital of Zhongshan University, Guangzhou 510080, Guangdong, CHINA
【Abstract】 Objective To investigate the curative effect of Yinxing Damo injection in the treatment of stable an-gina pectoris (SAP) and effect on vascular stiffness and endothelial injury markers. Methods From January 2015 to No-vember 2016, 52 patients with SAP treated in Department of Cardiovascular Medicine of our hospital were selected asthe research objects, which were divided into the observation group (n=26) and control group (n=26) according to therandom number table. Patients in the control group received symptomatic treatment with routine antiplatelet medicationand lipid regulation, while those in the observation group were additionally treated with Yinxing Damo injection plussymptomatic treatment, both 2 weeks. The number of weekly attacks, brachial ankle pulse wave velocity (ba-PWV) andperipheral blood endothelial progenitor cells (EPCs) after treatment were compared. Results After treatment, the angi-nal attacks in observation group was (2.45±0.59) times/week, significantly less than (4.67±1.86) times/week in the con-trol group (P<0.05). The ba-PWV in observation group was (1 401.7±165.3) cm/s, significantly lower than (1 533.8±176.6) cm/s in the control group, while peripheral blood EPCs was (0.027±0.011)% in observation group, significantlyhigher than (0.019±0.009)% in the control group (P<0.05). Conclusion Yinxing Damo injection in treatment of SAPcan effectively improve the vascular stiffness, increase the number of endothelial progenitor cells, and improve the clini-cal efficacy.
      【Key words】 Yinxing Damo injection; Stable angina pectoris; Vascular stiffness; Endothelial progenitor cells·论 著·doi:10.3969/j.issn.1003-6350.2017.12.006