标题：CYBA基因A640G多态性与精神分裂症易感性及认知功能的关系

      作者：罗旭东，林举达，邹晓波，叶小清
    （广东医科大学附属医院精神心理科，广东 湛江 524001）

      卷次： 2016年27卷15期

      【摘要】 目的 探讨NADPH氧化酶 p22phox亚基基因(CYBA基因) A640G多态性和精神分裂症的易感性及
其疾病严重程度、认知功能的相关性。方法 选取2013年1月至2015年8月在我院住院的406例中国汉族人群精
神分裂症患者作为观察组，选取同期到我院参加健康体检者 485例作为对照组，采集血标本提取DNA后应用
SNaPshot技术进行CYBA基因A640G多态性检测，比较两组受检者的基因型、等位基因频率分布差异；采用阳性和
阴性症状量表(PANSS)评估患者精神症状严重程度，采用简明精神分裂症认知评估测验(BACS)评估首发患者的认
知功能，比较观察组各基因型的PANSS、BACS量表的得分差异。结果 (1)观察组患者的GG、GA、AA基因型频率
和正常对照组比较差异均无统计学意义(41.6% vs 39.8%、45.8% vs 46.8%、12.6 % vs 13.4%，P>0.05)；G、A等位基因
频率和正常对照组比较差异均无统计学意义(64.5% vs 63.2%、35.5% vs 36.8%，P>0.05)；观察组患者GG、GA、AA基
因型的PANSS量表总分及各分量表的得分比较差异均无统计学意义(P>0.05)。(2) AA基因型患者在BACS量表语
义流畅性测验、字词流畅性测验平均分显著高于GG基因型患者且差异均有统计学意义[(42.30 ±15.30)分 vs
(33.93±11.23)分，(13.96 ±6.40)分 vs (10.51±5.09)分，P<0.05]。结论 CYBA基因A640G多态性与精神分裂症的认知
功能障碍存在明显相关，但与精神分裂症的易感性及其症状严重程度无明显相关。

      【关键词】 精神分裂症；NADPH氧化酶；基因多态性；认知功能；相关性

      【中图分类号】 R749.3 【文献标识码】 A 【文章编号】 1003—6350（2016）15—2424—04


Relationships between CYBA gene A640G polymorphism and susceptibility and cognitive function of
schizophrenia.
LUO Xu-dong, LIN Ju-da, ZOU Xiao-bo, YE Xiao-qing. Department of Psychiatry, Affiliated Hospital of
Guangdong Medical University, Zhanjiang 524001, Guangdong, CHINA

【Abstract】 Objective To investigate the relationship between the NADPH oxidase p22phox subunit gene (CYBA
gene) A640G polymorphism and susceptibility, disease severity, cognitive function of schizophrenia. Methods A total
of 406 Chinese Han Population patients with schizophrenic in our hospital from January 2013 to August 2015 were se-
lected as research group, and 485 healthy subjects for physical examination were enrolled as the control group. CYBA
gene A640G polymorphism was detected by SNaPshot after extracting DNA from blood samples, and the genotype and
allele frequency distributions between the two groups were compared. The positive and negative symptom scale
(PANSS) was used to assess the severity of psychiatric symptoms, and the congnitive function of first-episode patients
were assessed by brief assessment of cognition in schizophrenia (BACS). The scores difference of PANSS and BACS of
each genotype were compared in the research group. Results (1) There were no significant differences in GG, GA, AA
genotype frequency between the two groups (41.6% vs 39.8%, 45.8% vs 46.8%, 12.6 % vs 13.4%，P>0.05); G, A allele
frequency in research group and control group showed no statistically significant difference (64.5% vs 63.2%, 35.5% vs
36.8%, P>0.05). The PANSS scale total score and the scores of each component of GG, GA, AA genotype in research
group showed no statistically significant difference (P>0.05). (2) The average score of BACS volume table semantic flu-
·论 著·
6350.2016.15.004