标题：西地那非治疗顽固性高血压患者疗效观察

      作者：吴学正，刘先霞，陈磊，陈跃武    (海南医学院第二附属医院心内科，海南 海口 570311)

      卷次： 2017年28卷8期

      【摘要】 目的 观察枸橼酸西地那非对顽固性高血压患者的临床疗效。方法 选取 2013年 1月至 2016年10月海南医学院附属第二医院顽固性高血压住院患者 52例为观察对象，采用随机、单盲、安慰剂对照的方法分为西地那非组和安慰剂组各 26例，所有患者治疗 8周，通过治疗前、后 24 h动态血压变化评价西地那非对于顽固性高血压的疗效。结果 经过 8周治疗，西地那非组患者 24 h平均动脉压的降幅明显优于安慰剂组[收缩压(SBP)(-8.8±1.4) mmHg vs(1.3±1.2) mmHg；舒张压(DBP)(-5.3±3.3) mmHg vs (1.8±1.1) mmHg；平均动脉压(MBP)(-7.9±3.6) mmHg vs (0.8±0.9) mmHg]，血压降幅在白昼更加明显[SBP(-6.0±4.7) mmHg vs (4.4±1.5) mmHg；DBP(-4.6±4.1) mmHg vs (0.92±2.2) mmHg；MBP (-4.8±3.9) mmHg vs (3.5±1.4) mmHg]，差异均有统计学意义(P<0.05)。夜间血压两组患者差异无统计学意义(P>0.05)。结论 西地那非可用于顽固性高血压患者的治疗。
      【关键词】 顽固性高血压；西地那非；动态血压监测；平均动脉压
      【中图分类号】 R544.1 【文献标识码】 A 【文章编号】 1003—6350（2017)08—1324—03

Clinical observation of sildenafil in patients with resistant hypertension.
WU Xue-zheng, LIU Xian-xia, CHEN Lei,CHEN Yue-wu. Department of Cardiology, Second Hospital Affiliated to Hainan Medical College, Haikou 570311, Hainan,CHINA
【Abstract】 Objective To observe clinical effect of the sildenafil in patients with resistant hypertension.Methods A randomized, single-blinded, placebo-controlled clinical trial was adopted to divide 52 patients with resis-tant hypertension in Second Hospital Affiliated to Hainan Medical College from January 2013 to Oct 2016 into sildena-fil group (n=26) and placebo group (n=26). The treatment course of all the patients was 8 weeks. The 24-hour ambula-tory blood pressure changes before and after treatment were observed to evaluate the effect of sildenafil on resistant hy-pertension. Results After 8-week treatment, the reduction of 24-hour mean blood pressure of the patients in the silde-nafil group was significantly better than that in placebo group, systolic blood pressure (SBP) (-8.8±1.4) mmHg vs (1.3±1.2) mmHg, diastolic blood pressure (DBP) (-5.3±3.3) mmHg vs (1.8±1.1) mmHg, mean blood pressure (MBP) (-7.9±3.6) mmHg vs (0.8±0.9) mmHg. The daytime mean blood pressure of the patients in the sildenafil group was significant-ly better than that in placebo group, which were SBP (-6.0±4.7) mmHg vs (4.4±1.5) mmHg, DBP (-4.6±4.1) mmHg vs(0.92±2.2) mmHg, MBP (-4.8±3.9) mmHg vs (3.5±1.4) mmHg, showing the statistical differences (P<0.05). No statisti-cal difference in the nighttime mean blood pressure was found (P>0.05). Conclusion Sildenafil can effectively re-duce the artery blood pressure in patients with resistant hypertension.
      【Key words】 Resistant hypertension; Sildenafil; Ambulatory blood pressure monitoring; Mean arterial pressure·临床经验·doi:10.3969/j.issn.1003-6350.2017.08.041基金项目：海南省2014年社会发展科技专项基金（编号：SQ2014SHFZ0138）