标题：幽门螺杆菌对功能性消化不良患者胃肠激素的影响

      作者：孟王萍，邓明明    (西南医科大学附属医院消化内科，四川 泸州 646000)

      卷次： 2017年28卷8期

      【摘要】 幽门螺杆菌(Hp)是发现于胃黏膜上皮细胞表面的一种，能够导致胃上皮黏膜层的慢性炎症,全世界感染率约为50%。目前，Hp感染被认为是引起功能性消化不良(FD)症状的可能因素之一。FD常同时伴有胃肠症状和心理疾患，不明确的病因和难以缓解的症状最终导致患者焦虑、抑郁，而精神心理异常又通过多种机制加重FD症状。Hp感染功能性消化不良患者后可引起机体多种体液因子变化，如5-羟色胺、胃泌素、胃饥饿素、多巴胺等，从而影响包括中枢神经系统在内的多系统功能并出现相应症状表现。本文就幽门螺杆菌对功能性消化不良患者胃肠激素和焦虑抑郁情绪的影响做一综述。
      【关键词】 幽门螺杆菌；功能性消化不良；5-羟色胺；焦虑；抑郁
      【中图分类号】 R378.2 【文献标识码】 A 【文章编号】 1003—6350（2017）08—1314—04

Effect of Helicobacter pylori on gastrointestinal hormones in functional dyspepsia.
MENG Wang-ping, DENGMing-ming. Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000,Sichuan, CHINA【Abstract】 Helicobacter pylori (H. pylori) is a Gram-negative bacterium which was found in the surface of gastricmucosa epithelial cells. H. pylori can lead to chronic inflammation of gastric mucosa layer, and its prevalence is 50%around the world. At present, H. pylori infection is considered to be one of the possible factors which can cause function-al dyspepsia (FD). FD is known to be accompanied by gastrointestinal symptoms and psychological disorders, especiallyanxiety and depression, which might due to uncertain causes and difficult management. And mental disorders can wors-en the FD symptoms through various mechanisms. After infecting functional dyspepsia patients, H. pylori can inducechanges of humoral factors, such as serotonin, gastrin, gastric ghrelin, anddopamine, which can influence the function ofseveral systems with related symptoms, including central nervous system. This article is going to review the effects of H.pylori on gastrointestinal hormones and mental disorders in functional dyspepsia.
      【Key words】 Helicobacter pylori; Functional dyspepsia; Serotonin; Anxiety; Depression·综 述·doi:10.3969/j.issn.1003-6350.2017.08.038