标题:肾缺血再灌注损伤中蛋白激酶C对巨噬细胞的影响
作者:肖婷 综述 容松 审校 (遵义医学院附属医院肾内科,贵州 遵义 563003)
卷次:
2017年28卷8期
【摘要】 缺血再灌注损伤是器官移植不可避免的反应过程,其病理生理机制包括细胞凋亡、氧自由基生成、免疫系统活化、微血管功能障碍等。其中先天免疫是机体防御的第一道防线,也是关键环节,而巨噬细胞是肾脏缺血性先天免疫早期重要的起动子,在缺血再灌注损伤中发挥双剑作用。因此,在早期减轻巨噬细胞的浸润是目前的研究热点。而蛋白激酶C抑制剂能通过多途径作用减少移植肾内的巨噬细胞浸润,但目前具体机制尚不完全清楚。
【关键词】 肾缺血再灌注损伤;先天免疫;巨噬细胞;蛋白激酶C
【中图分类号】 R692 【文献标识码】 A 【文章编号】 1003—6350(2017)08—1302—04
Influence of protein kinase C on macrophages in renal ischemia-reperfusion injury.
XIAO Ting, RONG Song.Department of Nephrology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, CHINA【Abstract】 Ischemia-reperfusion injury (IRI) is inevitable for organ transplantation, and its pathophysiologicalmechanisms include apoptosis, generation of reactive oxygen species (ROS), innate immune system activation, microvas-cular dysfunction. The innate immune system is the first line of defense, also a critical component of organ transplanta-tion. Macrophages are the critical early initiator of innate immunity in the kidney, which play a dual role in renal isch-emia-reperfusion injury. Therefore, how to reduce macrophage infiltration is a hotspot of ischemia-reperfusion injury.Protein kinase C inhibitors can reduce macrophage infiltrate in the renal allografts through multiple pathways, but how itworks is still unclear.
【Key words】 Renal ischemia-reperfusion injury (IRI); Innate immune system; Macrophage; Protein kinase C(PKC)·综 述·doi:10.3969/j.issn.1003-6350.2017.08.034基金项目:国家自然科学基金(编号:81160096)
下载PDF