标题：超声造影联合常规超声诊断乳腺癌前哨淋巴结的价值

      作者：林婷婷 1，李迎春 2，赖锦彬 1，骆达林 3    (1.深圳市福永人民医院超声科，广东 深圳 518103；2.深圳市宝安区人民医院超声科，广东 深圳 518101；3深圳市宝安区人民医院放射科，广东 深圳 518101)

      卷次： 2017年28卷8期

      【摘要】 目的 探讨超声造影联合常规超声诊断乳腺癌前哨淋巴结的临床价值。方法 选取 2014年 3月至 2016年 3月间深圳市福永人民医院及深圳市宝安区人民医院诊治的乳腺癌女性患者 30例，分别对患者行常规超声和超声造影检查，观察常规超声、超声造影和超声造影联合常规超声对诊断乳腺癌前哨淋巴结准确性。结果 ①联合检测准确性、敏感性和特异性明显高于常规造影组，差异有统计学意义(P<0.05)，常规超声和超声造影相比、超声造影和联合检测相比，准确性、敏感性和特异性差异均无统计学意义(P>0.05)；②常规超声、超声造影以及两者联合检测乳腺前哨淋巴结ROC曲线面积分别为0.68、0.76和0.90，常规超声和超声造影曲线下面积均明显小于联合检测，差异均有统计学意义(P<0.01或<0.05)，而常规超声曲线下面积与超声造影比较差异无统计学意义(P>0.05)。结论 超声造影联合常规超声对乳腺癌前哨淋巴结诊断价值较高，值得在临床上推广应用。
      【关键词】 超声造影；超声；乳腺癌；前哨淋巴结；转移
      【中图分类号】 R737.9 【文献标识码】 A 【文章编号】 1003—6350（2017）08—1299—03

Value of contrast-enhanced ultrasound combined with conventional ultrasound in the diagnosis of sentinel lymphnode in breast cancer.
LIN Ting-ting 1, LI Ying-chun 2, LAI Jin-bin 1, LUO Da-lin 3. 1. Department of Ultrasound, thePeople's Hospital of Fuyong, Shenzhen 518103, Guangdong, CHINA; 2. Department of Ultrasound, the People's Hospital ofBaoan District of Shenzhen, Shenzhen 518101, Guangdong, CHINA; 3. Department of Radiology, the People's Hospital ofBaoan District of Shenzhen, Shenzhen 518101, Guangdong, CHINA
【Abstract】 Objective To evaluate the value of contrast-enhanced ultrasound combined with conventional ultra-sound in the diagnosis of sentinel lymph node in breast cancer. Methods Thirty cases of female patients with breastcancer in People's Hospital of Fuyong and People's Hospital of Baoan District of Shenzhen from Mar 2014 to Mar 2016were selected. The patients were examined by conventional ultrasound and contrast-enhanced ultrasound respectively.The diagnostic accuracy of sentinel lymph nodes in breast cancer was observed by conventional ultrasound, contrast-en-hanced ultrasound, and combination of the two. Results The accuracy, sensitivity and specificity of combined detec-tion were significantly higher than those of conventional ultrasound group, P<0.05. There was no significant differencebetween the conventional ultrasound and contrast-enhanced ultrasound in accuracy, sensitivity and specificity, and nei-ther between contrast-enhanced ultrasound and combined detection (P>0.05). The area of ROC curve of the breast senti-nel lymph nodes were 0.68, 0.76, 0.90 respectively, which were detected by conventional ultrasound, contrast-enhancedultrasound and combined detection. The area under the conventional ultrasound curve was significantly smaller than thecombined detection, P<0.01. The area under conventional ultrasound and contrast-enhanced ultrasound curve was signifi-cantly smaller than that of the combined detection (P<0.01 or P<0.05), but there was no significant difference betweenthe area under conventional ultrasound curve and contrast-enhanced ultrasound (P>0.05). Conclusion Contrast-en-hanced ultrasound combined with conventional ultrasound has a high value in the diagnosis of sentinel lymph node inbreast cancer, which is worthy of clinical promotion.
      【Key words】 Contrast-enhanced ultrasound; Ultrasound; Breast cancer; Sentinel lymph node; Metastasis·论 著·doi:10.3969/j.issn.1003-6350.2017.08.033